Drug development taste masking

Kayumba, P. C., Huyghebaert, N., Cordelia, C., Ntawukuliryayo, J. D., Vervaet, C., and Remon, J. P. (2007). Quinine sulphate pellets for flexible pediatric drug dosing Formulation development and evaluation of taste-masking efficiency using the electronic tongue. Eur. J. Pharm. Biophurm. 66,460-465. 

Sohi H. Sultana Y. Khar R. Taste masking technologies in oral pharmaceuticals Recent developments and approaches. Drug Dev Ind Pharm 2004 30(5) 429-48. 

The vast majority of salt forms are developed to enhance the aqueous solubihty of drug substances. In some cases, a salt may be preferred with reduced solubihty for use in suspension formulations where solubihty as low as possible is optimum to prevent Ostwald ripening, for taste masking or to prepare a sustained release product. Chlorpromazine is marketed as a tablet and syrup using the hydrochloride salt but the insoluble embonate salt is used in suspension formulations to extend the duration of achon and minimize taste problems. Occasionahy the selection of a salt with only modest aqueous solubihty may be more suitable for use in tablet products prepared by wet granulation. For example, prochlorperazine maleate is used in Stemehl tablets rather than the highly soluble mesylate salt. 

Fu Y, Yang S, Jeong SH, Kimura S, Park K. Orally fast disintegrating tablets developments, technologies, taste-masking and clinical studies. Grit Rev Ther Drug Carrier Syst 2004 21(6) 433-476. 

In drug development, CDs are used for increasing the water solubility of lipophilic compounds or, in contrast, for decelerating of the dissolution or biotransformation of very hydrophilic compoimds by their encapsulation in a hydrophobic CD-cavity, for preserving the odor of odorants or the taste of food additives, or for masking unpleasant odors and tastes. Selected examples of CD applications in drug development and technology are summarized in Table 10-2 [14], [15]. 

Hoang Thi TH, Morel S, Ayouni F, Flament MR Development and evaluation of taste-masked drug for paediatric medicines - Application to acetaminophen. Int J Pharm. 434 (1-2) 235-242, 2012. 

Guhmann, M., Preis, M., Gerber, F., Pdllinger, N., Breitkreutz, J., Weitschies, W., 2015. Design, development and in-vitro evaluation of diclofenac taste-masked orodispersible tablet formulations. Drug Dev. Ind. Pharm. 41, 540-551. 

Polymeric microparticles have been studied and developed for several years. Their contribution in the pharmacy field is of utmost importance in order to improve the efficiency of oral delivery of drugs. As drug carriers, polymer-based microparticles may avoid the early degradation of active molecules in undesirable sites of the gastrointestinal tract, mask unpleasant taste of drugs, reduce doses and side effects and improve bioavailability. Also, they allow the production of site-specific drug targeting, which consists of a suitable approach for the delivery of active molecules into desired tissues or cells in order to increase their efficiency. 

In an azithromycin dry syrup micronized crospovidone not only stabilizes the suspension physically but also maskes the bitter taste of the drug substance [615]. The formulation given in Table 145 was also developed on a laboratory scale and demonstrates the use of micronized crospovidone in an antiacid dry syrup from which a suspension is prepared as the administration form. 

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