Drug development future prospect

Workman, P. Enzyme-directed bioreductive drug development revisted a commentary on recent progress and future prospects with emphasis on quinone anticancer agents and quinone metabolizing enzymes, particularly DT-diaphorase. Oncol. Res. 1994, 6, 461 175. 

In the previous chapter (Chapter 21), we described how the pharma industry and the FDA work together today, respectively, to develop and approve new drugs, and to ensure their safe use in the marketplace. In this chapter, we consider the future course and prospects for regulation and drug development. 

Gali-Muhtasib H, Bakkar N. 2002. Modulating cell cycle Current applications and prospects for future drug development. Curr Cancer Drug Targets 2 309-336. 

Many organizations have responded to LC/MS because of some seemingly common motivating factors. These factors provide a perspective as to why LC/MS has become so prominent throughout the drug development cycle and provide unique insights into the future prospects for growth. 

The purpose of this overview chapter is to provide perspectives in the current status and future prospects of controlled release drug delivery. This is accomplished by examining various delivery systems from a mechanistic point of view, exploring applications of these systems, and discussing relevant biopharmaceutical parameters. A major section of this book is devoted to fundamental issues and applications of transdermal and transmucosal delivery systems (Chapter 6,8,17-23). Other developing systems of future potential... 

Ilium L (2012) Nasal drug delivery-recent developments and future prospects. J Control Release 161 254—263... 

Leppik IE (1994) Antiepileptic drugs in development prospects for the near future. Epilepsia 35(Suppl 4) S29-40... 

The question naturally arises, Do acute EPS increase the risk of TD If acute EPS do predict an increase in future TD, then the emergence of EPS indicates an increased need to terminate the medication. These questions have been debated over the years, but recent research gives the best-informed answer to date. In 2006 a prospective follow-up study of 9,298 patients by the European Schizophrenia Outpatient Health Outcomes (SOHO) Study found a statistically significant correlation between baseline EPS and later TD. According to Tenback et al. (2006), about half of the patients who developed tardive dyskinesia had earlier extrapyra-midal symptoms. They concluded that drug regimens... that increase extrapyramidal symptoms are likely to result in increased risk of tardive dyskinesia. ... 

Based on the major goal of preformulation—identification of possible failure in future development—numerous studies are performed to fully characterize prospective drug candidates. The major analytical technique in each preformulation group is liquid chromatography. Ninety percent of all analytical equipment in preformulation groups are HPLC systems equipped with UV and MS detection systems. HPLC is a fast and reliable method for concentration and identity determination by UV and/or MS detection, respectively. The type of HPLC methods differ based on the specific preformulation tests that will be described below. 

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