Registries drug-based

Several disease-based registries, sponsored by the drug manufacturers, have been established primarily for disorders in which there is commercially available treatment. Guidelines for the monitoring and treatment of the affected individual are being formulated under the auspices of various experts involved in these surveillance efforts (Martin et al., 2008 Muenzer et al., 2009). 

Capture-recapture models are another method based on probability considerations, which can be undertaken without additional field research.11 If in one register (e.g. arrest register) 5000 persons are found (for possession of heroin) and in a second register (e.g. treatment register) 2000 persons are found (for treatment of heroin abuse), and there are 400 persons who appear in both registries, it can be assumed that 20% (400/2000) of the drug addicts have been arrested, so that the total heroin addict population could be around 25,000 (5000/20%), five times larger than the total number of arrested heroin users. Results can usually be improved... 

Based on data submitted to the National Registry of Drug-Induced Ocular Side Effects and those acquired by other investigators, the following guidelines for the clinical use of 10% phenylephrine are suggested ... 

Shortly after this activity was initiated, the National Library of Medicine (NLM) and the Food and Drug Administration (FDA) were given responsibility for providing more specific access to health-related information about drugs and chemicals. It was decided at that time to build a data base from the chemical registry system which would fit the specific requirements of NLM and FDA. A subsidiary project was established with Chemical Abstracts Service as part of the chemical registry contract, which is administered by the National Science Foundation. The data base was built from information available in the files of NLM and FDA and from approximately 40 standard reference sources on drugs and chemicals. 

These sources included, among others, the U. S. Pharmacopoeia and the Merck Index. Thus, the common data base would contain compounds known to be of interest to people in the health field, including drugs, antibiotics, hazardous materials, pesticides, nutrients, and food additives as well as inert compounds in such substances. Chemical Abstracts Service processed these sources against its registry system and added registrations as well as synonyms as they were found in these standard references. The data were delivered to FDA and NLM in a form suitable for processing in their machine systems. 

A registry which has been used to collect data on biological therapies for rheumatoid arthritis is an example of one which is based on both disease and drugs. Registries which are disease-based offer greater flexibility in terms of study design - patients not exposed to particular drugs are useful for comparative purposes. 

Nervous system The effect of antiplatelet drugs on the risk of subarachnoid hemorrhage has not been accurately quantified. In a population-based case-control study using data from the Danish National Patient Registry, 1186 patients with a first episode of subarachnoid hemorrhage were... 

Robles-Diaz M, Lucena Ml, Kaplowitz N, Spanish DILI Registry, SLatinDILl Network, Safer and Faster Evidence-based Translation Consortium et al (2014) Use of Hy s law and a new composite algorithm to predict acute liver failure in patients with drug-induced liver injury. Gastroenterology 147 109-118.e5... 

Eurap Study Group. Utilization of antiepileptic drugs during pregnancy comparative patterns in 38 countries based on data from the EURAP registry. Epilepsia 2009 50(10) 2305-9. 

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