Adriamycin - Doxorubicin

AC, Adriamycin (doxorubicin), Cytoxan (cyclophosphamide) CAF, Cytoxan (cyclophosphamide), Adriamycin (doxorubicin), 5-fluorouracil CEF, cyclophosphamide, epirubicin, 5-fluorouracil CMF, cyclophosphamide, methotrexate, 5-flourouracil FAC, 5-fluorouracil, Adriamycin (doxorubicin), cyclophosphamide FEC, 5-fluorouracil, epirubicin, cyclophosphamide TAC, Taxol (paclitaxel), Adriamycin (doxorubicin), cyclophosphamide. 

What is the average intravenous dose of Adriamycin (doxorubicin) for... 

What is the average intravenous dose of Adriamycin (doxorubicin) for a child whose weight is 50 kg and height is 142 cm The average intravenous dose of doxorubicin for a child is 30 mg/m2. 

Cystostatic antibiotics insert themselves into the DNA double strand this may lead to strand breakage (e.g., with bleomycin). The anthracycline antibiotics daunorubkin and adriamycin (doxorubicin) may induce cardiomyopathy. Bleomycin can also cause pulmonary fibrosis. 

The chemotherapy of advanced Hodgkin s disease is one of the best examples of successful combination chemotherapy. Combination therapy with the MOPP regimen (mechlorethamine, Oncovin [vincristine sulfate], procarbazine, prednisone), alternating with ABVD (Adriamycin [doxorubicin hydrochloride], bleomycin, vinblastine, dacarbazine), has resulted in cure rates of 50 to 60%. 

S)-[ F]fluoroethylcarazolol 8, 111 subtypes of, 100 Adriamycine (doxorubicine), 589 Agrochemical agents, 215 AIF. See Aluminium monofluoride Aliphatic nucleophilic substitution, 28 Alkenes, as amide bond substitutes, 702-703 Alkenes fluorination, 18 Allyl hydrazines as SSAO inhibitors, 674 Aluminium monofluoride, 534 Alumino-fluoride complexes, 364 Alzheimer s disease (AD)... 

Anthracyclines are antitumor quinone containing antibiotics produced by different strains of Streptomyces. Some of them, such as adriamycin doxorubicin), and daunorubicin are broad spectrum antitumor compounds. They act by binding to DNA and interfering with DNA replication and gene transcription. Their limitations for clinical use are cardiac toxicity and drug resistance phenomena. Consequently, intense structure-activity relationship studies have been performed to improve the pharmacological profile as well as to enhance the affinity for DNA. In particular, a number of fluorinated anthracyclines have been prepared with introduction of fluorine atoms into D or A cycles, and into the aglycone side chain linked atC-14. ... 

Ten mice per group were immunized every 3rd day (five times). On the 3rd and 6th days after the last treatment the mice were exsanguinated and the sera stored at - 70 °C. Numbers represent an average of ten individually tested sera. P = HPMA copolymer backbone ADR = adriamycin (doxorubicin) gal = galac-tosamine bound via the NH2 group... 

P = HPMA copolymer backbone ADR = adriamycin (doxorubicin) gal = galactosamine bound via the NH2 group... 

Tertiary amine oxides and hydroxy la mines are also reduced by cytochromes P-450. Hydroxylamines, as well as being reduced by cytochromes P-450, are also reduced by a flavoprotein, which is part of a system, which requires NADH and includes NADH cytochrome b5 reductase and cytochrome b5. Quinones, such as the anticancer drug adriamycin (doxorubicin) and menadione, can undergo one-electron reduction catalyzed by NADPH cytochrome P-450 reductase. The semiquinone product may be oxidized back to the quinone with the concomitant production of superoxide anion radical, giving rise to redox cycling and potential cytotoxicity. This underlies the cardiac toxicity of adriamycin (see chap. 6). 

Figure 5-23 Stereoscopic drawing showing a molecule of daunomycin (Fig. 5-22) intercalated between two base pairs in a molecule of double-helical DNA, d(CGTACG). Nitrogen and oxygen atoms are shown as dots. From Quigley et al.220 Both daunomycin and adriamycin (doxorubicin 14-hydroxy-daunomycin) are important but seriously toxic anticancer drugs.

Diffuse histiocytic lymphoma Cyclophosphamide, Adriamycin (doxorubicin), vincristine, and prednisone (CHOP) bleomycin, Adriamycin (doxorubicin), cyclophosphamide, Oncovin (vincristine), and prednisone (BACOP) or cyclophosphamide, Oncovin (vincristine), methotrexate, and cytarabine (COMA). 

Adriamycin (Doxorubicin) Ajmaline Bulk HPLC Silica MeOH-O.OI MNH4CI04 GC [11] [3]... 

Adriamycin (doxorubicin) Cyclophosphamide Oncovin (vincristine) Procarbazine Prednisone Repeat every 21 days BEACOPP (escalated) Bleomycin Etoposide... 

Adriamycin (doxorubicin) Cyclophosphamide Oncovin (vincristine) Procarbazine... 

Figure 7.6. Drugs that are structural analogs of riboflavin and may cause deficiency. Relative molecular masses (Mr) riboflavin, 376.4 quinacrine, 472.9 (dihydrochloride) chlorpromazine, 318.9 imipramine, 280.4 amitryptyline, 277.4 and adriamycin (doxorubicin), 543.5.

Nevertheless, a few biosynthetic studies have shown that glycosyl transfer can occur much earlier, sometimes well before construction of the aglycon moiety is complete. In the perhaps best-known example, the biosynthesis of daunomycin (= daunorubicin, 29) and adriamycin (= doxorubicin, 30), glycosyl transfer of daunosamine is postulated to occur either at the aklavinone (38) stage [86], as in the biosynthesis of aclacinomycin A 37 (see above), or after 11-hydroxylation to -rhodomycinone [87], i. e., six to seven biosynthetic steps prior to completion of adriamycin formation (30, Scheme 17) [88]. 

Curran CF, Luce JK. Ocular adverse reactions associated with adriamycin (doxorubicin). Am J Ophthalmol 1989 108(6) 709-11. 

ABVD Adriamycin (doxorubicin) + bleomycin + CABG coronary artery bypass graft... 

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