Maintenance dose, specifying

For each study we specified the type of clinical study performed, the number of patients included, the duration of the study, its criteria for their inclusion, the methods employed to study the mite content of the environment when it was carried out (table 1), the therapeutic agents employed and the type of maintenance dose (table 2), the criteria chosen to assess the efficacy of sublingual desensitization, the results and adverse effects observed (table 3). 

To specify a maintenance dose amount and frequency. Intuitively, the maintenance dose might be half the initial/priming dose at intervals equal to its plasma tj, for this is the time by which the plasma concentration that achieves the desired effect declines by half. Whether or not this approach is satisfactory or practicable, however, depends very... 

Normal CCr may be considered as lOOml/minute once the CCr and LBM have been calculated the loading dose (initial dose) required to reach a certain serum concentration and the maintenance dose to maintain the specified concentration can be calculated. The loading dose (LD) is based solely on the LBM of the patient. The maintenance dose (MD) is based on LBM and the renal clearance rate of the drug. 

The third part, perhaps the most significant, contains the synthesis of various important members treated individually, brief description of the synthesis, therapeutic applications of each compound, together with its dosage in various diseases, and routes of administration. The dosage for adults and children have been separately mentioned. The usual and maintenance doses, wherever applicable, have also been specified. The mode of action of various classes of medicinal compounds in addition to the structure-activity relationship (SAR) have also been elaborated wherever relevant. Greater emphasis has been laid on the chemistry of various compounds treated in this book, so that an undergraduate student may acquire a comprehensive knowledge on the basic concepts of the medicinal chemistry. 

The requirement to access cells for maintenance purposes and to transfer full product containers to the vitrified product store offers the potential for >1-Sv doses to operators under fault conditions. In order to prevent such incidents, entries to cells are controlled via inner and outer shield doors that are interlocked to gamma monitors. Additionally Operating Rules and Instructions place requirements on operators with regard to man entries to cells and prohibit the presence or introduction of active product containers to specified cells. Personal Alarmed Dosimeters are routinely worn during cell entries to provide an immediate indication of high dose rates. 

Provisions should be made for shielding the radiation sources, in addition to those provisions required during operation, to ensure that personnel can have access to and can occupy the plant control room or the supplementary control points (e.g. the location of the remote shutdown panel) so as to operate and maintain essential equipment without exceeding established dose limits as specified in paras V.27-V.32 of the BSS [2] and paras 4.57-4.65 of Ref. [20]. This includes access to equipment in cases where maintenance or repair may be necessary after an accident. In general, provision should be made to render direct intervention by operators superfluous by instaUing automatic or remote controlled equipment (e.g. remote controlled valves). 

Infrequent refuelling, integral design of primary circuit and reduced piping are also specified as factors contributing to the minimization of occupational doses (IRIS, SCOR, VBER-300) achieved though the resulting reduced maintenance. 

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