Dorsal root ganglion cell

A1 adenosine receptors are inhibitory in the central nervous system. A receptors were originally characterized on the basis of their ability to inhibit adenylyl cyclase in adipose tissue. A number of other G-protein-mediated effectors of A receptors have subsequently been discovered these include activation of K+ channels, extensively characterized in striatal neurons [13], and inhibition of Ca2+ channels, extensively characterized in dorsal root ganglion cells [14]. Activation of A receptors has been shown to produce a species-dependent stimulation or inhibition of the phosphatidylinositol pathway in cerebral cortex. In other tissues, activation of A receptors results in synergistic activation of the phosphatidylinositol pathway in concert with Ca2+-mobilizing hormones or neurotransmitters [15]. The effectors of A adenosine receptors and other purinergic receptor subtypes are summarized in Table 17-2. 

Schirrmacher K, Busselberg D, Langosch JM, Walden J, Winter U, Bingmann D. (1999). Effects of (+/-)-kavain on voltage-activated inward currents of dorsal root ganglion cells from neonatal rats. Eur Neuropsychopharmacol. 9(1-2) 171-6. 

Ohkubo T, Kitamura K. (1997). Eugenol activates Ca(2-i-)-permeable currents in rat dorsal root ganglion cells. J Dent Res. 76(11) 1737-44. 

Zhang, J.-M, Donnelly, D. F., Song, X.-J., LaMotte, R. H. Axotomy increases the excitability of dorsal root ganglion cells with unmyelinated axons, J. Neurophysiol. 1997, 78, 2790-2794. 

Bleakman, D., Brorson, J.R., Miller, R.J. The effect of capsaicin on voltage-gated calcium currents and calcium signals in cultured dorsal root ganglion cells, Br. J. Pharmacol. 1990, 101, 423-431. 

Cardenas CG, Del Mar LP, Scroggs RS. Two parallel signaling pathways couple 5HT1A receptors to N- and L-type calcium channels in C-like rat dorsal root ganglion cells. J Neurophysiol 1997 77 3284-3296. 

Eberhart C E, Dubois R N 1995 Eicosanoids and the gastrointestinal tract. Gastroenterology 109 285-301 Ennes H S, Young S H, Raybould H E et al 1997 Intercellular communication between dorsal root ganglion cells and colonic smooth muscle cells in vitro. Neuroreport 8 733-737... 

Silperisone (32) is a sodium channel blocker acting centrally as a muscle relaxant. The compormd has been in preclinical animal studies [81, 82] and has been proposed recently to have potential as an antispastic drug in demyelinating diseases such as multiple sclerosis. In vivo, silperisone depressed ventral root reflexes and excitability of motoneurons. Whole-cell measurements in dorsal root ganglion cells revealed that silperisone depressed voltage gated sodium channel conductance at concentrations that inhibited spinal reflexes. 

Hanesch, U., Pfrommer, U., Grubb, B.D. etal. (1993). The proportion of CGRP-immunoreactive and substance P-mRNA containing dorsal root ganglion cells is increased by a... 

Matsuda Y, Yoshida S, Yonezawa T 1978 Tetrodotoxin sensitivity and Ca component of action potentials of mouse dorsal root ganglion cells cultured invitro. Brain Res 154 69—82... 

Traditionally, the dorsal root ganglion (DRG) has been used as a model of the peripheral nerve because of its more convenient size, location, and the ability to correlate cell size and neurochemical phenotype with peripheral axon caliber. Hohmann and Herkenham (1999a,b) used in situ hybridization to test the hypothesis that dorsal root ganglion cells, the source of primary afferent input to the... 

Phenotypes of Dorsal Root Ganglion Cells Expressing CBI Rs and CBI R mRNA... 

The differences in colocalization reported here may he attributed to differences between native and cultured dorsal root ganglion cells and/or the use of different antibodies recognizing different epitopes of CBIR. Lower numbers of TRPVl immunoreactive cells are observed in DRG cultures raised in the absence of neurotrophic factors, but no changes are observed in the number of CBi-expressing cells under these same conditions (Ahluwalia et al. 2002). Elimination of neurotrophic factors from culture media is also associated with a modest but significant shift in the distribution of the size of CBlR-immunoreactive cells to larger diameters (Ahluwalia et al. 2002). 

Hanesch U, Blecher F, Stiller RU, Emson PC, Schaible HG, Heppelmann B (1995) The effect of a unilateral inflammation at the rat s ankle joint on the expression of preprotachykinin-A mRNA and preprosomatostatin mRNA in dorsal root ganglion cells—a study using non-radioactive in situ hybridization. Brain Res 700 279-284... 

Reduction in sodium currents in squid giant axons (Takenaka et al., 1987 Takenaka et al., 1988) and dorsal root ganglion cells cultured in PUFA containing media (Park Ahmed, 1992) has been reported earlier. We have tested whether PUFAs have a similar action on sodium currents in pyramidal neurons from the hippocampal CAl area. Our... 

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