Domain regulation

B. and Willson, T.M. (2003) X-ray crystal structure of the liver X receptor (> ligand binding domain regulation by a histidine-tryptophan switch. The Journal of Biological Chemistry, 278, 27138-27143. 

Fulop, V., Bocskei, Z., and Polgar, L. Prolyl Oligopeptidase An Unusual -Propeller Domain Regulates Proteolysis. Cell 1998, 94, 161-170. 

Modular Protein Interaction Domains Regulate Dynamic Cellular Behaviour... 

Kinase domain Regulated by kinase function Regulated by kinase structure... 

Stommel JM, Marchenko ND, Jimenez GS, Moll UM, Hope TJ, Wahl GM (1999) A leucine-rich nuclear export signal in the p53 tetramerization domain regulation of subcellular localization and p53 activity by NES masking. EMBO J 18 1660-1672... 

Touhara, K. Binding of multiple ligands to pleckstrin homology domain regulates membrane translocation and enzyme activity of -adrenergic receptor kinase. FEBS Lett., 417, 243-248 (1997)... 

Rotblat, B., Prior, LA., Muncke, C, Parton, R.G., Kloog, Y., Henis, Y.I., and Hancock, J.F. (2004). Three separable domains regulate GTP-dependent association of H-ras with the plasma membrane. Mol Cell Biol 24 6799-6810. 

Imamura F, Maeda S, Doi T, Fujiyoshi Y. Ligand binding of the second PDZ domain regulates clustering of PSD-95 with the Kvl. 4 potassium channel. J Biol Chem 2002 277 3640-3646. 

Okabe S, Miwa A, Okado H. 1999. Alternative splicing of the C-terminal domain regulates cell surface expression of the NMDA receptor NR1 subunit. J. Neurosci. 19 7781-92... 

Structurally Diverse Activation and Repression Domains Regulate Transcription... 

Venkataraman, K., and Futerman, A. H. Do longevity assurance genes containing Hox domains regulate cell development via ceramide synthesis FEBS Lett 528 (2002a) 3-4. 

In two-component systems in bacteria (Fig. 4), signal perception by the A -terminal domain of the sensor (which is usually located in the periplasmic space flanked by two or more transmembrane domains) results in autophosphorylation of a carboxyl-terminal histidine kinase domain, the phosphate group is then transferred to an aspartate residue in the A -terminal of the receiver domain of the response regulator which in turn via the output domain regulates its activity - for example as a transcriptional activator [42]. 

Brown LS, Var6 G, Hatanaka M et al. The complex extracellular domain regulates the transient deprotonation and reprotonation of the retinal Schiff base during the bacteriorhodopsin photocycle. Biochemistry 1995 34 12903-12911. 

Ma, P.C. et al, c-Met mutational analysis in small cell lung cancer novel juxtamembrane domain regulating cytoskeletal functions. Cancer Res., 63,2003 (in press). 

Burridge K, Nuckolls G, Otey C et al (1990) Actin-membrane interaction in focal adhesions. Cell Differ Dev 32 337-342 Calalb MB, Polte TR, Hanks SK (1995) Tyrosine phosphorylation of focal adhesion kinase at sites in the catalytic domain regulates kinase activity a role for Src family kinases. Mol Cell Biol 15 954-963 Calderwood DA, Tuckwell DS, Humphries MJ (1995) Specificity of integrin I-domain-ligand binding. Biochem Soc Trans 23 504S... 

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