Prolyl oligopeptidases

At the C-terminus, prolyl oligopeptidase (postproline endopeptidase, EC 3.4.21.26) cleaves the C-terminal dipeptide [178]. The resulting oxytocin-(1-7) is also a substrate for aminopeptidase. Furthermore, neprilysin (EC 3.4.24.11) can also play a role in oxytocin degradation, although it seems to act with less efficiency than the two other enzymes. 

Fulop, V., Bocskei, Z., and Polgar, L. Prolyl Oligopeptidase An Unusual -Propeller Domain Regulates Proteolysis. Cell 1998, 94, 161-170. 

T. Tarrago, S. Frutos, R.A. Rodriguez-Mias, E. Giralt, Identification by F-19 NMR of traditional Chinese medicinal plants possessing prolyl oligopeptidase inhibitory activity, Chembiochem 7 (2006) 827-833. 

Polgar, L. 2002. The prolyl oligopeptidase family. Cell Molec. Life Sci. 59 349-362. 

Tarrago T, Masdeu C, Gomez E et al (2008) Benzimidazolium salts as small, nonpeptidic and BBB-permeable human prolyl oligopeptidase inhibitors. Chem Med Chem 3 1558-1565... 

Garcia-Horsman JA, Mannisto PT, Venalainen JI. On the role of prolyl oligopeptidase in health and disease. Neuropeptides 2007 41 1-24. 

Quantitative structure-activity relationship of prolyl oligopeptidase inhibitory peptides derived from b-casein using simple amino acid descriptors... 

Clan SC contains peptidases with the a/P hydrolase fold bearing the catalytic triad in the order Ser, Asp, His. This clan includes the families (characteristic member in parentheses) S9 (prolyl oligopeptidase), S10 (carboxypeptidase C), S15 (Xaa-Pro dipeptidyl -peptidase), S28 (lysosomal Pro-Xaa carboxypeptidase), S33 (prolyl amino-peptidase), and S37 (Streptomyces PS-10 peptidase). The characteristic catalytic dyad Ser, Lys of dan SE is represented by the motif Ser-Xaa-Xbb-Lys, and the fold consists of helices and an a + P sandwich. The families of this clan Sll (penicillin-binding protein 5), S12 (Streptomyces R61 D-Ala-D-Ala carboxypeptidase), S13 (penicillinbinding protein 4) are involved in the biosynthesis, turnover and lysis of bacterial cell walls. 

Proliferation, 1448,2321, 2404, 3525 Proliferation of smooth muscle cells, 2298 Proliferative effect, 2399,2402 Proline, 50,1571 Proline redox cycle, 1571 Prolonged nerve block, 66 Prolyl oligopeptidase (POP), 1309 Promastigotes, 845, 1266,1290 Promiscuous tmzymes, 1666 Promyelocytic cell lines, 3561 Pronase E, 1085 Pro-oncogene MDM2, 2404 Pro-oxidant respmise, 2370 Propeller, 2777... 

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