DNA single-strand breaks

ASTLEY s B, ELLIOTT R M, ARCHER D B and souTHON s (2002) Increased cellular carotenoid levels reduce the persistance of DNA single strand breaks following oxidative chaUange. Nutrition and Cancer. In press. 

Bradley MO. 1985. Measurement of DNA single-strand breaks by alkaline elution in rat hepatocytes. In Ashby J, de Serres FJ, et al., eds. Progress in mutation research. Vol. 5. Evaluation of short- term tests for carcinogens. Amsterdam, The Netherlands Elsevier Science Publishers, 353-357. 

Martin, L. J. and Liu, Z. Injury-induced spinal motor neuron apoptosis is preceded by DNA single- strand breaks and is p53- and Bax-dependent. /. Neurobiol. 50 181-197, 2002. 

In single dose oral studies with rats, endrin treatment was associated with an increased incidence (2.4-3.5-fold) in the number of DNA single strand breaks in hepatocytes (Bagchi et al. 1992a, 1993a, 1993c Hassoun et al. 1993). DNA damage was attributed to oxidative injury caused by endrin. 

Hassoun, EA Creighton University Assess abilities of endrin to induce the formation of reactive oxygen species and lipid peroxidation and DNA single strand breaks that result in oxidative stress in fetuses of pregnant mice. The protective effects of some antioxidants will also be assessed using this model. 

Hassoun E, Bagchi M, Bagchi D, et al. 1993. Comparative studies on lipid peroxidation and DNA-single strand breaks induced by lindane, DDT, chlordane and endrin in rats. Comp Biochem Physiol 104C(3) 427-431. 

Ward, J.F., Blakely, W.F., and Joner, E.I., 1985, Mammalian cells are not killed by DNA single-strand breaks caused by hydroxyl radicals from hydrogen peroxide, Radiat.Res. 

LOMEFLOXACIN t UVA IS min Figure19.3 Useofsupercoiled plasmid circular DNA for detection of ROS production by photo-activated lomefloxacin. Form I supercoiled form (no DNA breaks) form II relaxed form (few DNA single strand breaks) form III linearform (high level of DNA single strand breaks leading to double strand breaks see [38]). 

Genotoxicity. Cigarette smoke, administered to male ICR mice, produced DNA single-strand breaks measured 15, 30, 60, 120, and 240 minutes after the exposure. Fifteen minutes after the animals were exposed for 1 minute to a sixfold dilution of smoke, the effect appeared in the lungs, stomach, and liver. The damage in the lungs and liver returned to almost control levels by 60 minutes and the stomach by 120 min-... 

NT044 Tsuda, S., N. Matsusaka, S. Ueno, N. Susa, and Y. F. Sasaki. The influence of antioxidants on cigarette smoke-induced DNA single-strand breaks in mouse organs a preliminary study with the alkaline single cell gel electrophoresis assay. Toxicol Sci 2000 54(1) 104-109. 

DNA single-strand breaks, Fischer 344 rat liver in vivo... 

DNA single-strand breaks were not induced by di(2-ethylhexyl) phthalate in primary cultures of rat or Syrian hamster hepatocytes or in Chinese hamster ovary (CHO) cells. Unscheduled DNA s5uithesis was not induced in rat or mouse primary hepatocytes exposed to di(2-ethylhexyl) phthalate. Only one of six studies reported induction of gene mutations at the Tk locus in mouse l5unphoma L5178Y cells exposed to di(2-ethylhexyl) phthalate in the absence of an exogenous metabolic activation system. Ouabain-resistant mutants were not induced in mouse lymphoma or BALB/c-3T3 cells. 

Boekelheide, K. (1993) Sertoli cell toxicants. In Russell, L.D. Griswold, M.D., eds. The Sertoli Cell, Clearwater, FL, Cache River Press, pp. 551-575 Bove, J.L., Dalven, P. Kukreja, V.P (1978) Airborne di-butyl and di(2-ethylhexyl)phthalate at three New York City air sampling stations. Int. J. environ. Chem., 5, 189-194 Bradley, M.O. (1985) Measurement of DNA single-strand breaks by alkaline elution in rat hepatocytes. Prog. Mutat. Res., 5, 353-357... 

The role of CYP2E1 in a-oxidation of A-nitrosodiethanolamine was probed by using the deuterated isotopomers A-nitroso[a-D4]diethanolamine and 7V-nitroso-[P-D4]diethanolamine. 7V-Nitrosodiethanolamine and 7V-nitroso[P-D4]diethanolamine were equally cytotoxic to human CYP2E1-transfected V79 cells, while 7V-nitroso-[a-D4]diethanolamine was not. Significant DNA single-strand break levels were... 

DNA repair) in male Swiss albino mouse liver, lung and kidney in vivo DNA single-strand breaks, Sprague-Dawley rat liver in vivo DNA single-strand breaks, male Wistar rat liver in vivo... 

DNA single-strand breaks were induced in vitro by 7V-nitrosodiethanolamine in rat, hamster and pig hepatocytes. However, no DNA single-strand breaks were found in Chinese hamster embryo cells, in a human l5miphoblastoid cell line or in rat and human kidney cells in vitro. 

Chang, C. M., Hsia, M. T., Stoner, G. D. Hsu, I. C. (1990) Acrylonitrile-induced sister-chromatid exchanges and DNA single-strand breaks in adult human bronchial epithelial cells. Mutat. Res., 241, 355-360... 

DIA, DNA single-strand breaks, CD-I mouse splenocytes in vitro... 

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