Organisms mouse

Eukaryotic organisms Mouse lymphoma cells L5178Y Gene mutation (+) — Oberly et al. 1982... 

Benzyl chloride also induced in vitro cellular transformation in Syrian hamster embryo cultures and DNA alkylation in several organs of the male mouse following iv adrninistration. In summary, lARC states there is limited evidence that benzyl chloride is carcinogenic in experimental animals epidemiological data was inadequate to evaluate carcinogenicity to humans (67). 

Ben2oate esters, like most organic esters, are not very toxic. They are not absorbed through the skin as rapidly as alkyl esters but are more potent physiologically. They are also moderate skin irritants. The oral LD qS (mouse) for methyl- to butyUiydroxy ben2oates range between 8 and 5 g/kg. 

The phthalate esters are one of the most widely used classes of organic esters, and fortunately they exhibit low toxicity (82). Because of the ubiquitous nature of phthalates, many iavestigations have been conducted to determine their toxicides to marine life as well as ia mammals (83—85). Generally, phthalates are not absorbed through the skin and are not very potent when inhaled. The phthalates become less toxic as the alcohol group increases in molecular weight. For example, dimethyl phthalate has an oral LD q (mouse) of 7.2 g/kg, whereas di(2-ethylhexyl) phthalate shows an oral LD q (rat) of greater than 26 g/kg. 

Palytoxin isolated from zoanthids Palythoa spp. is known to be extremely lethal (0.5 fig/kgy mouse, i.p.) and to have the most complicated natural product structure (Figure 4) ever elucidated (13,14). The toxin was later revealed to be a potent tumor promoter (15). Yet, health risks due to the toxin have remained unclear, as the zoathids are the most unlikely organisms to be regarded as foodstuff. Recently, however, data are being compiled to indicate the wide distribution of this toxin among marine biota. 

Mazzullo M, Bartoli S, Bonora A, et al. 1992. In vivo and in vitro interaction of trichloroethylene with macromolecules from various organs of rat and mouse. Res Commun Chem Pathol Pharmacol 76 192-208. 

HARA T, MUKUNOKIY, TSUKAMOTO I, MiYOSHi M, HASEGAWA K (1984) Susceptibility of Kintoki bean lectin to digestive enzymes in vitro and its behavior in the digestive organs of mouse in vivo. J Nutr Sci Vitaminol (Tokyo). 30 381-94. 

Nitrosating agent in various mouse organs effect of adding morpholine to homogenates of different organs of mice exposed to 23 ppm NO for 5 h, with analysis for NMOR by the Iqbal method... 

Sasaki, Y.F. et al., The comet assay with 8 mouse organs results with 39 currently used food additives, Mutation Res., 519, 103, 2002. 

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