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DNA effects

Atienzar FA, Billinghurst Z, Depledge MH (2002) 4-n-Nonylphenol and 17-beta estradiol may induce common DNA effects in developing barnacle larvae. Environ Pollut 120 735-738... [Pg.107]

DNA effects Damage to DNA (Deoxyribonucleic acid) by a chemical or material may result in genotoxic effects such as mutations, which in turn may lead to carcinogenicity. Damage to DNA causes the cell to manufacture new DNA to compensate for the loss or damage. This can be assessed by evaluating the formation of newly synthesized DNA. Unscheduled DNA Synthesis... [Pg.178]

Assays for DNA Effects DNA damage and repair unscheduled DNA synthesis in vitro / ... [Pg.192]

ICH guidelines specifically require three genotoxicity assays for all devices (see Table 6.2). The assays should preferably evaluate DNA effects, gene mutations and chromosomal aberrations, and two of the assays should preferably use mammalian cells. Guidance for providing tests for selection to meet these needs are the OECD guidelines, which include 8 in vitro and 7 in vivo assays. [Pg.193]

Schaberle FA, Kuz min VA, Borissevitch IE (2003) Spectroscopic studies of the interaction of bichromophoric cyanine dyes with DNA. Effect of ionic strength. Biochim Biophys Acta 1621 183-191... [Pg.157]

P.-G. Wu, L. Song, J. B. Clendenning, B. S. Fujimoto, A. S. Benight, and J. M. Schurr, Interaction of chloroquine with linear and supercoiled DNAs. Effect on the torsional dynamics, rigidity, and twist energy parameter, Biochemistry 27, 8128-8144 (1988). [Pg.224]

Meneghini R. 1974. Repair replication of opossum lymphocyte DNA Effect of compounds that bind to DNA. Chem Biol Interact 8 113-126. [Pg.125]

NDPA has exhibited genotoxicity in bacteria Salmonella typhimurium, Escherichia colt) and mammalian cells (mouse lymphoma, Chinese hamster) and caused DNA effects (fragmentation, unscheduled synthesis, repair) in rat hepatocytes and chromosome aberrations in Chinese hamster cells. ... [Pg.535]

Valeraldehyde caused chromosomal and DNA effects in mammalian cells in culture but was not mutagenic in an Ames bacterial test." ... [Pg.726]

Electron Transfer in Bromine-Substituted DNA Effect of the Disruption of Base Stacking... [Pg.124]

Cai Z, Gu Z, Sevilla MD (2001) Electron spin resonance study of electron and hole transfer in DNA effects of hydration, aliphatic amine cations and histone proteins. J Phys Chem B 105 6031-6041 Cai Z, Li X, Sevilla MD (2002) Excess electron transfer in DNA effect of base sequence and proton transfer. J Phys Chem B 106 2755-2762... [Pg.452]

Nunez ME, Hall DB, Barton JK (1999) Long-range oxidative damage to DNA effects of distance and sequence. Chem Biol 6 85-97... [Pg.469]

O Neill P (1989) Pulse radiolysis of DNA - effects of environment. Free Radical Res Commun 6 153-154... [Pg.469]

Atienzar, F.A., Cheung, V.V., Jha, A N. and Depledge, M.H. (2001) Fitness parameters and DNA effects are sensitive indicators of copper-induced toxicity in Daphnia magna, Toxicological Sciences 59 (2), 241-250. [Pg.35]

Gay M, Montana AM, Moreno V, Prieto M-J, Perez JM, Alonso C (2006) Studies of interaction of trichloro r 2-cis-N, N-dimethyl-l-[6-(N , N -dimethyl-ammoniummethyl)-cyclohex-3-ene-l-yl]-methylammonium platinum(II) chloride with DNA effects on secondary and tertiary structures of DNA. Cytotoxic assays on human ovarian cancer cell lines, resistant and non-resistant to cisplatin. Bioorg Med Chem 14 1565-1572... [Pg.54]

FOLINATE RALTITREXED Theoretical risk of 1 efficacy of raltitrexed Folinate antagonizes the anti-DNA effect of raltitrexed Be aware watch for poor response to raltitrexed... [Pg.307]

Table 9. Epidermal UV-B filtering capacity of leaves of selected high elevation plant species in the Venezuelan paramo (3000-4400 m asl) including the calculated biologically and DNA effective radiation reaching the mesophyll. Phenotypes G = glabrous, P = pubescent. Data from Robberecht et al. 1980. Table 9. Epidermal UV-B filtering capacity of leaves of selected high elevation plant species in the Venezuelan paramo (3000-4400 m asl) including the calculated biologically and DNA effective radiation reaching the mesophyll. Phenotypes G = glabrous, P = pubescent. Data from Robberecht et al. 1980.
Species Phenotype Transmitance (%) SE (305 nm) Biologically effective flux J DNA effective flnx J... [Pg.952]

Douki T., Angelov D., Cadet J., UV Laser photolysis of DNA effect of duplex stability on charge-transfer efficiency, J. Am. Chem. Soc., 2001,123, 11360-11366. [Pg.189]

See other pages where DNA effects is mentioned: [Pg.471]    [Pg.178]    [Pg.1032]    [Pg.57]    [Pg.1478]    [Pg.17]    [Pg.742]    [Pg.60]    [Pg.457]    [Pg.459]    [Pg.568]    [Pg.363]    [Pg.151]    [Pg.540]    [Pg.217]    [Pg.291]    [Pg.293]    [Pg.298]   
See also in sourсe #XX -- [ Pg.177 , Pg.178 , Pg.180 ]



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Benzofuranoid terphenyls effect on DNA, RNA, protein

Biological Effects Implying DNA as Target

Biological Effects not Involving DNA

DNA damage effect

Effect of VSV on Cellular and Viral DNA Synthesis

Effect on DNA

Effect on DNA structure

Effect on DNA synthesis in LLC

Effects of Brussels Sprouts on Oxidative DNA Damage

Effects on DNA Synthesis

Effects on DNA, Genes, and Chromosomes

Field-Effect DNA Sensing

Field-effect devices label-free electrical DNA detection

Field-effect devices polyelectrolyte layers and synthetic DNA

Field-effect-based DNA sensors

LLC cells DNA synthesis effect of oleic acid

Metallo-Base Pair in DNA and Its Effect on Thermal Stability

Physical Effects on DNA

Pironetin effect on DNA content

Pisiferic acid effects on DNA synthesis

Protection from Cellular Effects of DNA Damage

Reovirus Effects on Host Cell DNA Synthesis

Solvent effects on excited states of DNA bases

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