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Vincristine displays limited myelosuppression but its neurotoxicity is dose limiting. On the other hand the most important toxicity of vinblastine is myelosuppression while it lacks serious risks for neurotoxicity. The toxicity spectrum of vindesine and of vinorelbine is between these two extremes. The vinca alkaloids can cause inappropriate secretion of antidiuretic hormone. 

Figure 3. Phase diagram for a two-component system with no intermediate compounds displaying limited solid solubility for a and...

The intermediate fluorinated organolithium compounds display limited stability at low temperature, but can be transmetalated to stable organotin compounds. Pyrolysis then affords highly reactive fluoroacetylenes, e. g. 2.150... 

Antibodies display limited thermal and chemical stability. Their binding site may be altered or blocked during immobilization processes. However, the binding site of MIPs is very stable and robust, even under harsh conditions. 

Elastoplastic copolymers derived from D -DiSiAn in which n is between 10 and 30 exhibited high ultimate elongations. However, the materials displayed limited recoverable elongation. DMA of a typical elastoplastic revealed a weak thermal transition around 75 corresponding to the organic imide hard block. The small size and dispersivity of the hard blocks in these systems may inhibit the microphase separation necessary for development of true elastomeric properties. 

Some proteins are quite rigid, whereas others display limited flexibility. Rigid units can function as structural elements in the cytoskeleton (the internal scaffolding within cells) or in connective tissue. Parts of proteins with limited flexibility may act as hinges, springs, and levers that are crucial to protein function, to the assembly of proteins with one another and with other molecules into complex units, and to the transmission of information within and between cells (Figure... 

Unlike their counterparts in skin, the epidermal Lange-rhans cell (LC) population, respiratory tract DC populations display limited expression of intracellular Birbeck granules (Bg). These are found only occasionally in sections of normal lung tissue in mouse and human lung and airway tissue samples (Hanau etaL, 1985 Sertl etal., 1987 Soler et al., 1989) and are virtually absent in rat (P.G. Holt, unpublished). They are found in increased frequency in airway tissues of human smokers (Soler et 0.1., 1989), which suggests that Bg expression may require local stimulation for initial induction (Hanau et al., 1985). 

A class of compounds with a high affinity for e.g. dopamine D2 receptors are the hydroxylated 2-aminotetralins, e.g. 5-OH-DPAT (9), N-0437 (31), 7-OH-DPAT (10) and 5,6-di-OH-DPAT (81). Preclinical data show that these compounds display limited activity upon... 

Complex 15 illustrates the importance of incorporating an N, 0-chelate of sufficient steric bulk on an electrophilic metal center to achieve overall improved reactivity. While these room temperature transformations are promising, this complex is not thermally robust and thus displays limited substrate scope. In particular, heating to promote reactivity with unstrained internal alkenes or challenging N-heterocyclic substrates results in no appreciable product formation and catalyst decomposition, as noted by NMR spectroscopy. 

Pd-only TWCs display limitations with respect to their ability to reduce NO and, particularly, in their selectivity towards N2 at low temperature.67,68 Modification of Pd by the introduction of a second, cheaper metal would appear to offer a viable solution from an economical and catalytic point of view.69 It is well known that the resulting bimetallic catalyst may display special features not anticipated by simple interpolation of the reactivity of the constituents. Although the complexity of TWC systems, where the metal components can be present over the alumina and/or the promoter makes the study of bimetallic systems rather difficult, the main physicochemical effects exerted by the second metal on the noble metal component allow a simple classification of bimetallic systems, somewhat independent of the specific kinetic and thermodynamic features of the metal-metal contact. First of all, catalysts are found where the introduction of the second metal (M) may generate a binary phase, either in the oxidised and/or reduced chemical states. This is typically the case for Cu70 71 or Cr.36,56 A classic explanation of the differential behavior with respect to the monometallic Pd system makes use of the interrelated structural (or ensemble) and electronic effects. This is typically applied to the zero-valent state but can also loosely embrace oxidised or partially reduced states where the noble metal displays catalytic activity.56 As previously mentioned, NO reduction (by CO) is... 

Two general conclusions may be drawn from the foregoing discussion. First, the interpretation of data from experiments on bioconcentration of xenobiotics should recognize possible complications from the effects of metabolism and excretion, and second that even when aquatic organisms, such as leaches, mussels, or crustaceans that are assumed to display limited metabiolic potential for xenobiotics, are used for monitoring purposes, interpretation of the data should consider the possibility of metabolism and excretion after initial exposure to the toxicant. 

Peptide catalysts, peptides that catalyze chemical reactions such as aldol, retro-aldol, and Michael reactions. In contrast to enzymes or catalytic antibodies ( abzymes), small peptides often display limited catalytic activity and substrate specificity. Combinatorial methods combined with reaction-based or catalysis-based high-throughput selection approaches are suited for catalyst optimization [E. Tanaka, Chem. Record 2005, 5, 276]. 

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