Disease chemotherapy

Britto, C. C. (2009). Usefulness of PCR-based assays to assess drug efficacy in Chagas disease chemotherapy Value and limitations. Mem. Inst. Oswaldo Cruz 104(Suppl. 1), 122-135. 

Rodriques Coura J, de Castro SL. A critical review on Chagas disease chemotherapy. Mem Inst Oswaldo Cruz 2002 97(l) 3-24. 

Retinoids - Physiological effect. 2. Retinoids - Therapeutic use. 3. Vitamin A - Physiological effect. 4. Vitamin A - Therapeutic use. 5. Cancer - Chemotherapy. 6. Skin - Diseases - Chemotherapy. I. Livrea, Maria A., 1946-. II. Series. 

Keywords Pentose phosphate pathway, glucose-6-phosphate dehydrogenase, transketolase, NADPH, nucieotide biosynthesis, glutathione, metabolic diseases, non-metabolic diseases, cancer, epilepsy, Alzheimer s disease, chemotherapy, gene therapy, chemoresistance, metabolomics, metabolic flux analysis, novel drug discovery and development. 

The development of injectable mictocapsules for deUvery of chemotherapy agents remains another active area of research. The ultimate goal is to achieve targeted deUvery of chemotherapy agents to specific sites in the body, ideaUy by injection of dmg-loaded mictocapsules that would seek out and destroy diseased ceUs. Intra-arterial infusion chemotherapy is a direct approach to targeted deUvery. The clinical appHcations of microspheres and mictocapsules in embolization and chemotherapy have been assessed (49) (see Chemotherapeutics, anticancer). 

Impla.nta.ble Ports. The safest method of accessing the vascular system is by means of a vascular access device (VAD) or port. Older VAD designs protmded through the skin. The totally implanted ports are designed for convenience, near absence of infection, and ease of implantation. Ports allow dmgs and fluids to be deUvered directiy into the bloodstream without repeated insertion of needles into a vein. The primary recipients of totally implanted ports are patients receiving chemotherapy, bolus infusions of vesicants, parenteral nutrition, antibiotics, analgesics, and acquired immune disease syndrome (AIDS) medications. 

Infusion devices have been used for diabetes, cancer chemotherapy, pain control (patient-controUed analgesia, ie, PGA), infection, Alzheimer s disease, Parkinson s, nausea, thalassemia, thromboembolism, and to treat severe spasms resulting from spiaal cord iajury (140—143). 

In the treatment of human neoplastic diseases methotrexate has largely supplanted aminopterin in chemotherapy, due to the better therapeutic index of the former in experimental animals, although this superiority over (325) has not been conclusively demonstrated in man. 

Mustard gas, used in chemical warfare in World War I, has been found to be an effective agent in the chemotherapy of Hodgkins disease. It can be produced according to the following reaction ... 

Chemotherapy is the control and treatment of disease by synthetic drugs. Most of these are organic compounds, often of remarkably simple structure. Sulfanilamide is one example of an organic compound synthesized by chemists for the treatment of bacterial infections. 

Cancer or neoplastic disease is a genomic disorder of the body s own cells which start to proliferate and metastasize in an uncontrolled fashion that is ultimately detrimental to the individual. Antineoplastic agents are used in conjunction with surgery and radiotherapy to restrain that growth with curative or palliative intention. The domain of antineoplastic chemotherapy is cancer that is disseminated and therefore not amenable to local treatment modalities such as surgery and radiotherapy. 

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