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Novel drugs, discovery

Watkins, L. R. and Maier, S. F. Glia a novel drug discovery target for clinical pain. Nat. Rev. DrugDiscov. 2 973-985,2003. [Pg.937]

Mousa SA. Anti-integrin as novel drug-discovery targets potential therapeutic and diagnostic implications. Curr Opin Chem Biol 2002 6 534 1. [Pg.82]

L. J. Gershell and J. H. Atkins, A brief history of novel drug discovery technologies, Nature Rev. Drug Discovery 2 (2003), 321-327. [Pg.633]

Even the best efforts of drug developers will not reduce the time and cost of drug discovery and development. However, as novel drug discovery and potential for development characterization techniques are put into place and the ICH process is more fully implemented, the time and cost will not increase as rapidly as in the past. [Pg.2506]

Raddatz, R., Schaffhauser, H., Marino, M. J. Allosteric approaches to the targeting of G-protein-coupled receptors for novel drug discovery a critical assessment. Biochem. Pharmacol. 2007, 74, 383—391. [Pg.84]

Quinolinic Acid in Neurological Disease Opportunities for Novel Drug Discovery... [Pg.524]

In this chapter, we will first discuss the basic principles of DNA-templated organic synthesis, as it is the mechanistic foundations for DNA-encoded libraries then we will discuss the progressive development of DNA-templated libraries and the evolution into a novel drug discovery tool. We will also discuss the DNA-recorded library, which also encodes library molecules with DNA but is conceptually different. These discussions will naturally involve specific drug discovery programs in which these libraries were applied and finally, we will discuss the outlook of DNA-eneoded libraries in the future of drug discovery. [Pg.261]

R. Powers, K. A. Mercier and J. C. Copeland, The Application of FAST-NMR for the Identification of Novel Drug Discovery Targets , Drug Discov. Today, 2008, 13, 172. [Pg.53]

Keywords Pentose phosphate pathway, glucose-6-phosphate dehydrogenase, transketolase, NADPH, nucieotide biosynthesis, glutathione, metabolic diseases, non-metabolic diseases, cancer, epilepsy, Alzheimer s disease, chemotherapy, gene therapy, chemoresistance, metabolomics, metabolic flux analysis, novel drug discovery and development. [Pg.2]

Congenital Heart Disease 85 Novel Drug Discovery 1... [Pg.145]


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