Discover platform

The CEM Discover platform, introduced in 2001, offers a single-mode instrument based on the self-tuning circular waveguide technique (see Fig. 3.3). This concept allows for derivatization of the reactor to accommodate additional application-specific modules to address other common laboratory objectives. While the Discover ... 

Fig. 3.22 Available variations of the CEM Discover platform BenchMate, Voyager, Investigator, and Explorers (clockwise). 

Similarly, the CEM Discover platform (Fig. 2) allows a 100-fold scale-up of small-scale batch synthesis when switching from the standard vial (0.5-5.0 mL operation volume) to the large reaction vessel (50 mL maximum filling volume). Automation is only possible for the small standard vials with the Explorer robotic extension (24 x 5.0 mL) but the large vessel can be utilized for SF processing as well [27,39]. 

With those single-mode reactors that do not require a minimum filling volume (CEM Discover platform temperature measurement is performed from the bottom and not from the side by an external IR sensor) even volumes as low as 50 xL can be processed [57]. With the commercially available singlemode cavities of today, the largest volumes that can be processed under sealed vessel conditions are ca 50 mL, with different vessel types being available to upscale in a linear fashion from 0.05 to 50 mL. Under open vessel conditions higher volumes (> 1000 mL) have been processed under microwave irradiation conditions, without presenting any technical difficulties as, e.g., described for the synthesis of various ionic liquids on a 2 mol scale [35]. 

Routine temperature measurement within the Discover series is achieved by means of an IR sensor positioned beneath the cavity below the vessel. This allows accurate temperature control of the reaction even when using minimal volumes of materials (0.2 mL). The platform also accepts an optional fiber-optic temperature sensor system that addresses the need for temperature measurement where IR technology is not suitable, such as with sub-zero temperature reactions or with specialized reaction vessels. Pressure regulation is achieved by means of the IntelliVent pressure management technology. If the pressure in the vial exceeds 20 bar, the... 

Johnston, P.A. and Johnston, P.A., Cellular platforms for HTS three case studies, Drug Discov. Today, 7, 353, 2002. 

Wick, 1., and Hardiman, G. (2005) Biochip platforms as functional genomics tools for drug discovery. Curr. Opin. Drug Discov. Dev. 8,347-354. 

Nicholson JK, ConneUy J, Lindon JC, Holmes E. Metabonomics a platform for studying drug toxicity and gene fimction. Nat Rev Drug Discov 2002 1 153-61. 

Lai Y, Asthana A, Kisaalita WS (2011) Biomarkers for simpKfymg HTS 3D cell culture platforms for drug discovery the case for cytokines. Drug Discov Today 16 293-297... 

Koch WH. Technology platforms for pharmacogenomic diagnostic assays. Nat Rev Drug Discov 2004 3 749-76L... 

Another annoying feature of most audit assessment tools is that they provide information about the vulnerabilities found, and not the ones that do not exist in the information system. It is therefore difficult to practice anticorrelation and degrade the severity of events that are not security risks for the information system. To obtain this effect, we currently manually maintain a set of simple rules indicating which vulnerability sets cannot be found in our corporate network. For example, we exclude all IIS vulnerabilities from events coming from hosting zones, as we do not offer this platform in our services. Note that we do not consider here the case where the vulnerability assessment tool fails to discover the vulnerability. Audit information is considered trusted. 

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