Dimethyl histamine

Many frogs contain high levels of N-methyihistamine and V,7V-dimethyl-histamine in their skin. Although such simple methylated derivatives can be considered alkaloids, they will not be treated as such in this review (see Refs. 1 and 5 for structures and tabulation of occurrence in amphibians). 

In this paper, we have calculated the theoretical PA s relative to the ammonia, in the gas phase, of the following compounds histamine (4(5)-2 -aminoethylimidazole) (1), 2-methyl-histamine (2), 2-amino-histamine (3), 4-methyl-histamine (4), 4-chloro-hista-mine (5), 4-nitro-histamine (6), Na-methyl-histamine (7), N ,Na-dimethyl-histamine... 

When the Mayo Clinic biochemists improved their methods so that they could separate the two compounds, they found, as before, that 1,4-methyl histamine predominates in the gastric mucosa, but they found that A -dimethyl histamine is the major metabolite of histamine in gastric juice (Table 5-2). Three years later. Code found that all histamine metabolites were present in the gastric juice secreted by a completely isolated, perfused canine stomach in the same proportions his colleagues had previously found in gastric juice of intact animals. Therefore, N-meth-ylated histamine is produced in the stomach itself. " ... 

At about this time, drugs blocking the action of histamine on gastric secretion became available, and Code at once found that such drugs block the secretory stimulating power of A-methyl histamine and A-dimethyl histamine. ... 

Synthesis of model systems analogous to histamine led to the pharmacologically interesting aminoethylpyrazoles.32-34 Dimethyl-carbamates and dialkylphosphates of 5-hydroxypyrazoles have been used practically as choline esterase inhibitors.35-41 Such compounds as Isolan (2), Pyrolan (3), and Pyrazoxon (4), which are too toxic for pharmacology, are used as systemic insecticides. There is evidence that 3,5-dimethylpvrazole has a stimulating action on plants.42... 

Uchida M, Ohba S, Ikarashi Y et al. (1993) Effect of the novel histamine H2 antagonist 5,6-dimethyl-2-[4-[3-(l-piperidinomethyl)phenoxy]-(z)-2-butenylamino]-4(lH)-pyrimidone dihydrochloride on histamine-induced gastric secretion in Heidenhain pouch dogs. Arzneim Forsch/Drug Res 43 873-876... 

Tricyclic Antidepressants. Irnipramine [50 9-7] (32), which was the first tricydic antidepressant to be developed, is one of many usefiil psychoactive compounds derived from systematic molecular modifications of the antihistamine promethazine [60-87-7] (see HiSTAMINE AND HISTAMINE antagonists). The sulfur atom of promethazine was replaced with an ethjiene bridge and the dimethyl amino group attached to an -propyl group, rather than to an isopropji one, of the side chain. The actual synthesis of (32) is typical of the compounds in this class (37). 

Basta SJ, Savarese JJ, Ali HH, Moss J, Gionfriddo M. Histamine-releasing potencies of atracurium, dimethyl tubocurarine and tubocurarine. Br J Anaesth 1983 55(Suppl l) S105-6. 

McCullough LS, Stone WA, Delaunois AL, Reier CE, Hamelberg W. The effect of dimethyl tubocurarine iodide on cardiovascular parameters, postganglionic sympathetic activity, and histamine release. Anesth Analg 1972 51(4) 554-9. 

Histamine-releasing potencies of atracurium, dimethyl tubocurarine and tubocurarine. Br J Anaesth... 

Synonyms Zantac Histamine blocker Antacid N,N-Dimethyl-5-(2-(l-methylamino-2-nitrovinyl-amino)-ethylthiomethyl)furfurylamine Chemical/Pharmaceutical/Other Class A competitive inhibitor of the H2 receptor located on the gastric parietal cells Chemical Structure ... 

Another labelling agent suitable for determination by HPLC of histamine, tyramine, phenylethylamine, tryptamine, cadaverine, putrescine, spermidine and spermine in wines is 4-(4-dimethyl-aminophenylazo)benzenesulfonyl (dabsyl) chloride (see Figure 4.14) (Bockhardt et al., 1996 Romero et al., 2000). 

The major components of ishiru flavor [3] are aldehydes such as 2-methyl butanal, pyrazines such as methylpyrazine, and ketones such as 2-butanone and dimethyl disnlfide. Trimethylamine, a smell compound often found in fish products, was not detected. Histamine and spermidine are the two major polyamines found in ishiru... 

LVWWS. J Bufotenine (N,N-Dimethyl-5-hydroxytryptamine) Histamine (Imidazolylamine)... 

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