Diisopropyl methylphosphonate DIMP

Army. 1978. Toxicity study in rats dosed with diisopropyl methylphosphonate (DIMP) in their drinking water. Aberdeen Proving Ground, MD Army Armament Research and Development Command. NTIS No. AD-A054-733. 

Bucci TJ, Parker RM, Wustenberg W. 1992. A 90-Day oral toxicity study and a 5-day metabolism study of diisopropyl methylphosphonate (DIMP) in mink. Jefferson, AR Pathology Associates, Inc. NTIS No. AD-A257-397. 

Dacre JC, Rosenblatt DH. 1987. Drinking water criteria for the groundwater pollutant diisopropyl methylphosphonate (DIMP). Fort Detrick, MD Army Biomedical Research and Development Lab. NTIS No. AD-A186-562. 

EPA. 1989. Health advisory for diisopropyl methylphosphonate (DIMP). U.S. Environmental Protection Agency, Office of Drinking Water. NTIS No. PB90-273517. 

Geary RS, Wall CM, Miller MA, et al. 1994. Partition coefficient measurements of diisopropyl methylphosphonate (DIMP) and trichloroethylene in rats using microdialysis and incorporated in physiologically-based pharmacokinetic (PBPK) modelling [Abstract], Society of Toxicology 33rd Annual Meeting, Dallas, TX 13-17 March, 1994. Paper No. 82. 

Ivie GW. 1980. Fate of diisopropyl methylphosphonate (DIMP) in a lactating cow. Bull Environ Contam Toxicol 24(l) 40-48. 

Palmer JS, Cysewski SJ, Crockshank HR, et al. 1979. Toxicologic evaluation and fate of diisopropyl methylphosphonate (DIMP) and dicyclopentadiene (DCPD) in cattle. College Station, TX Science and Technology Administration. NTIS No. AD-A093-673. 

Van Voris P, Cataldo DA, Ligotke MW, et al. 1987. Acute environmental toxicity and persistence of selected chemical agent simulants diisopropyl flourophosphate (DFP) and diisopropyl methylphosphonate (DIMP). NTIS No. AD-A181-309. 

Weiss DJ, Wustenberg W, Bucci TJ, et al. 1992. Hematologic alterations in mink induced by diisopropyl methylphosphonate (DIMP) [Abstract]. Toxicol Pathol 20 646. 

Impurity Diisopropyl methylphosphonate (DIMP) (1445-75-6) High low volatility water-soluble resistant to hydrolysis slow biodegradation RfD 80 pg/kg/day ... 

GB manufactured in the USA was at least 93% pure. Impurities may include diisopropyl methylphosphonate (DIMP), a stable byproduct of manufacture, and methylphosphonic difluoride. DIMP is usually present at 2-3% in isopropyl methylphosphonate waste and is present in sampling wells, both on and off the RMA (Rosenblatt et al., 1995 Aulerich et al, 1979). In 1974, DIMP concentrations of 0.5 pg/1 (the limit of detection) to 44000 pg/1 were found in the groundwater near the Arsenal (Robson, 1981). 

Study No. TP-001, Two-Generation Reproductive Study in Mink Fed Diisopropyl Methylphosphonate (DIMP), Final Report. Frederick, MD Pathology Associates International. 

DMMP), dimethyl phosphonate (DMHP) or diisopropyl methylphosphonate (DIMP) are commonly used as simulants. For nitroaromatic detection, 2,4-dinitrotoluene (2,4-DNT) is a commonly used simulant, although many TNT-based explosives often have a significant component of 2,4-DNT in the vapor signature. 

Two types of SPME fibers (Supelco, Inc.) were evaluated for each analyte 100-pm polydimethyl-siloxane and 85-pm polyacrylate coatings. Samples were then analyzed directly by GC-MS (Varian Saturn IV D) or derivatized on fiber first, then analyzed by GC-MS. The on-fiber derivatization procedure is accomplished by gently coating the SPME fiber with N,0-bis(trimethylsilyl)-trifluoroacetamide (BSTFA) prior to GC-MS analysis. The sample matrices analyzed in this study included soil leachate (sandy loam, Oakley, CA), simulated sea water (Instant Ocean, Aquarium Systems Co., Mentor, OH), and canal water (rain runoff, Livermore, CA). The chemical signatures we selected for the proliferation of CW included dimethyl methylphosphonate (DMMP), diisopropyl methylphosphonate (DIMP), 1,4-dithiane, thiodiglycol (TDG), and 2-(diisopropylamino)ethanol (DIAE). 

Palmer, J.S., Cysewski, S.J., Crockshank, H.R. et al. (1979) Toxicologic Evaluation and Fate of Diisopropyl Methylphosphonate (DIMP) and Dicyclopentadiene (DCPD) in Cattle, National Technical Information Service, Springfield, VA. 

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