Diethylstilbestrol

Figure 10.3-25. a) Structure of diethylstilbestrol (DES) b) 3 D pharmacophore query of DES two hits were found c) estrone and d) estradiol. 

The compound shown is diethylstilbestrol (DES) it has a number of therapeutic uses in estrogen replacement therapy DES is not a steroid but can adopt a shape that allows it to mimic estrogens such as estradiol (p 1100) and bind to the same receptor sites Construct molecular models of DES and estradiol that illustrate this similanty in molecular size shape and location of polar groups... 

Diethylstilbestrol Lemale genital tract - carcinoma (transplacental)... 

Fig. 38 Companson of manual dipping (A) with mechanized dipping (B) on the basis of scans and calibration curves [114] — 1 = cM-diethylstilbestrol, 2 = traw-diethylstilbestrol, 3 = ethinylestradiol Scanning curve 2 ng of each substance per chromatogram zone = 313 nm, /n > 390 nm Dipping solution water — sulfuric acid — methanol (85 + 15 + 1)...

Table 18. Statistical comparison (F-test [125]) of the methods. Standard deviation Sxo of the calibration curves for diethylstilbestrol and ethinylestradiol [114].

Liquid paraffin — triethanolamine cis/trans- diethylstilbestrol, ethynylestradiol 3-fold chloroform—liqmd paraffin — triethanolamine (60 -1-10 -1-10) [257]... 

Fig. 1 Fluorescence scan of a blank (A) and of a diethylstilbestrol-ethinylestradiol mixture (B), each with 10 ng substance per chromatogram zone. Start (1), cis-diethylstilbestrol (2), trans-diethylstilbestrol (3) ethonsylestradiol (4), front (5).

Detection and result The chromatogram was dried in the air, immersed in the reagent solution for 5 s and then heated to 120°C for 5 min. cis-Diethylstilbestrol hR( 15 — 20) and trawj-diethylstilbestrol (JtRf 40—45) turned red while ethynylestradiol (hRf 50—55) appeared blue. 

In situ quantitation The absorption photometric analysis was made at A = 540 nm (ethynylestradiol) and X = 605 nm (diethylstilbestrol). The detection limit for ethynylestradiol was 12ng and that for diethylstilbestrol 3 ng per chromatogram zone. 

Diethyl aniline, 54 Diethylcarbaniazine citrate, 54 Diethyl carbamyl chloride, 54 Diethyl chlorophosphate, 54 Diethylene triamine, 54 Diethyl ether, 54 Di(2-ethylhexyl) phthalate, 54 Diethyl ketone, 54 Diethyl-p-phenylenediamine, 54 Diethyl phthalate, 54 Diethylstilbestrol, 55 Diethyl sulfate, 55 Diethyl zinc, 55 Difluoromethane chloride, 55 Digitoxin, 55 Diglycidyl ether, 55 Digoxin, 55 Diisobutyl ketone, 55 Diisopropylamine, 55 Diisopropyl ether, 55 DIKAMIN , 2,4-D, 55 DIKONIRT , 2,4-D, 55 Dimefox, 55 Dimethoate, 55 3,3 -Dimethoxybenzidine, 55 n,n-Dimethylacetamide, 56 Dimethylamine, 56 4-Dimethylaminoazobenzene, 56 Dimethylaminoethanol, 56 n,n-Dimethyl aniline, 56 7,12-Dimethylbenz[a]anthracene, 56 3,3 -Dimethylbenzidine, 56... 

Dicyclomine 1, 36 Dienestrol 1, 102 Diethyl carFamazine 1, 278 Diethylstilbestrol I, 101 Diethylthiambutene 106... 

A solution of 30 parts by weight of pinacolin alcohol in ether is saturated with hydrogen chloride at room temperature and the ether solution then agitated with bicarbonate. After concentration by evaporation it leaves behind the crude diethylstilbestrol [a,j3-(p,p -dihydroxy-diphenyl)-Oi, 3from benzene, melts at 170°C to 171 °C. The yield amounts to 75% of the calculated. The total y eld of diethylstilbestrol, calculated on p-hydroxypropiophenone, is 68% of the theoretical. 

Diethylcarbamyl chloride Diethylcarbamazine citrate Diethyl carbonate Fenspiride Flurbiprofen Furaltadone Nifuratel Protizinic acid Diethylchlorophosphate Echothiopate iodide 0 ,0i -Dlethyl-4,4 -dihydroxystilbene Diethylstilbestrol diphosphate... 

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