Diethylcarbamazine citrate

Other pharmaceutical chemicals such as calcium gluconate, ferrous salts, nikethamide, glycerophosphates, chloral hydrate, saccharin, antihistamines (including meclozine, and buclozine), tranquilizers (including meprobamate and chloropromazine), antifilarials, diethylcarbamazine citrate, and oral antidiabetics, including tolbutamide and chloropropamide ... 

Diethylcarbamyl chloride Diethylcarbamazine citrate Diethyl carbonate Fenspiride Flurbiprofen Furaltadone Nifuratel Protizinic acid Diethylchlorophosphate Echothiopate iodide 0 ,0i -Dlethyl-4,4 -dihydroxystilbene Diethylstilbestrol diphosphate... 

Diethylcarbamazine citrate (Hetrazan) is active against several microfilaria and adult filarial worms. It interferes with the metabolism of arachidonic acid and blocks the production of prostaglandins, resulting in capillary vasoconstriction and impairment of the passage of the microfilaria. Diethylcarbamazine also increases the adherence of microfilariae to the vascular wall, platelets, and granulocytes. 

Diethylcarbamazine citrate (9.118), a synthetic piperazine derivative, is used for the treatment of filariasis and loiasis. Although its mechanism of action is basically unknown, it appears to somehow alter the surface structure of the helminth, rendering it more susceptible to destruction by the host defenses. 

All solvents and chemicals were HPLC grade. Organic solvents, sodium carbonate (anhydrous), and sodium bicarbonate were purchased from Fisher Scientific (Fair Lawn, NJ, USA). Carbonate buffer, pH = 10.0, was prepared using the sodium carbonate (anhydrous), and sodium bicarbonate. A solution of 0.1 % triethylamine in methanol was made for the elution solvent. Diethylcarbamazine citrate was obtained from Sigma, and used to make stock solutions (St. Louis, MO, USA). The internal standard, 1-diethylcarbamyl-4-ethylpiperazine (E-DEC) was synthesized by the Division of Medicinal and Natural Products Chemistry at the University of Iowa, College of Pharmacy. Ultra-pure analytical grade Type I water was produced by a Milli-Q Plus water system (Millipore Corporation, Bedford, MA, USA). For the extraction of DEC and of its internal standard, Alltech Extract - Clean C18 cartridges, 500 mg with a 2.8 mL reservoir, and a SPE vacuum manifold (Alltech, Deerfield, IL, USA) were used. 

Kumar K, Chakrabarti T, Srivastava GP. Studies on the sustained release tablet formulation of diethylcarbamazine citrate (Hetra-zan). Indian J Pharm 1975 37 57-59. 

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