Diethylamino-methoxy

Chlor-chlormethyl-methyl- E2, 280 Chlor-(2-cyan-propyl)-ethyl- E2, 10 (2-Chlor-eyclohexyl)-diethylamino-methoxy- E2,... 

To a mixture of 0.30 mol of l-diethylamino-4-methoxy-2-butyne (see Chapter V, Exp. 15) and 175 ml of dry diethyl ether were added 2.5 g of copper(I) bromide. 

Pyran-4-one, 2,6-bis(diethylamino)-3,5-diphenyl-conformation, 3, 622 Pyran-4-one, 2-chloromethyl-5-methoxy-benzothiazoles from, 3, 713 Pyran-4-one, 3,5-diacyl-IR spectra, 3, 595 Pyran-4-one, 3,5-dibenzyl-IR spectra, 3, 595... 

Q lllllflCrillC [Atebrine, 3-chloro-9(4-diethylamino-l-methyl)butylamino-7-methoxy)acridine] dihydrochloride. [69-05-6] M 472.9, m 248-250 (dec), pK -6.49 (aq H2SO4), pKj 7.73 (ring NH ), pKj 10.18 (Et2N). Cryst from H2O (sol 2.8% at room temp) as yellow crystals. Slightly sol in MeOH and EtOH. Antimalarial, antiprotozoal and intercalates DNA. [Wolfe Antibiot 3 (Springer-Verlag) 203 1975.]... 

The kineties of nueleophilie substitution of the methoxy group in methoxy-butenone by the diethylamino group has been studied (91MIl).Thus, the reae-tions of 4-heterobut-3-en-2-ones with amines presented below often involve the transamination step. 

RN 51012-32-9 MF C15H24N2O4S MW 328.43 EINECS 256-907-9 CN iV-[2-(diethylamino)ethyl]-2-methoxy-5-(methylsulfonyl)benzamide... 

Preparation of 2 -Anilino-6 -diethylamino-3 -methylfluoran (77d). To a solution of 2-(4-diethylamino-2-hydroxybenzoyl)benzoic acid (0.1 mol) in 98% sulfuric acid (1 50 g) was added 4-methoxy-2-methyldiphenylamine (0.1 mol) in limited amounts, while the temperature was maintained to not rise above 30 °C. The resulting mixture was stirred at room temperature for 20 h, and poured into ice water (1000 ml). The precipitate was filtered off, washed with water, and then refluxed with a mixture of toluene (400 ml) and 20% aqueous sodium hydroxide (150 g) for 1 h. The toluene layer was separated, washed with hot water, and concentrated to leave ca. 100ml of toluene. The residue was then refluxed with methanol (100 ml) for 1 h. After being cooled, the precipitate is filtered off, washed with methanol, and dried to give 2 -anilino-6 -diethylamino-3 -methylfluoran in 90% yield as an off-white powder, mp 197-198 °C. 

Preparation of 6 -Diethylamino-2 -(2,4-dimethyIaniIino)-3 -methylfluoran (77e). To a solution of 2-(4-diethylamino-2-hydroxybenzoyl)benzoic acid (0.1 mol) in 98% sulfuric acid (150 g) was added 4-methoxy-2,2, 4 -trimethyldiphenylamine (0.1 mol) in limited amounts, while the temperature... 

Similarly, the electrooxidation of alcohols carrying a /I-methoxy or f-diethylamino group leads to the corresponding cleavage products in high yields [13]. 

Quinacrine Quinacrine, 6-chloro-9-(4-diethylamino-l-methylbntylamino)-2-methoxy-acridine (37.1.4.3), is synthesized from 6,9-dichloro-2-methoxyacridine (37.1.4.2) and aforementioned 4-diethylamino-l-methylbutylamine (37.1.1.2). The 6,9-dichloro-2-methoxyacridine (37.1.4.2) necessary for the synthesis is made in two stages. The initial reaction of 2,4-dichlorobenzoic acid and p-anizidine in the presence of copper dnst and potassium carbonate gives 2-(4-methoxyanilino)-4-chlorobenzoic acid (37.1.4.1), which upon reaction with phosphorus oxychloride turns into the necessary 6,9-dichloro-2-methoxyacridine (37.1.4.2) [33-38]. 

Substituted quinazoline derivatives can be prepared by thermal ring contraction of 3/7-1,4-benzodiazepines <1999H(51)2407>. Both 5-methoxy 981 and 5-diethylamino-3/7-l,4-benzodiazepines 983 have been converted to the analogous 4-substituted quinazolines 982 and 984. 

TRYPTAMINE, N,N-DIETHYL-5-METHOXY INDOLE, 3-[2-(DIETHYLAMINO)ETHYL]-5-METHOXY N,N-DIETHYL-5-METHOXYTRYPTAMINE 3-[2-(DIETHYLAMINO)ETHYL]-5-METHOXYINDOLE... 

The hydrogenation of 2-diethylamino-6-methoxy-3-methyl-4//-pyran (96a) on Pd-charcoal led to hydrogenolytic ring cleavage, yielding 60% of... 

The hydroxyl group of ethyl 2-hydroxy-4-oxo-4//-pyrimido[2,l-a]-isoquinoline-3-carboxylate (20) was methylated with methyl iodide in dry boiling acetone for 5 h in the presence of potassium carbonate, with dimethyl sulfate in methylene chloride in methanol in the presence of Triton B at 20°C for 18 h, with methyl fluorosulfonate in 2.5 M sodium hydroxide at 20°C for 5 h, and with diazomethane in a mixture of diethyl ether and methylene chloride at 20°C for 3 h to give the 2-methoxy derivative (89AJC2161). The hydroxy group of 3-hydroxymethyl-4//-pyrimido[2,l-b]-isoquinolin-4-one was alkylated and acylated with 2-(diethylamino)ethyl chloride in dimethylformamide in the presence of sodium hydroxide, and with acetic anhydride in boiling chloroform in the presence of triethylamine and a few drops of 4-dimethylaminopyridine, respectively (86EUP 166439). 

The comparison of three coumarin compounds, 4-(bromomethyl)-7-methoxy-coumarin (Br-MMC), 7-(diethylamino)coumarin-3-carbohydrazide (DCCH), and 7-(diethylamino)-3-[(4-(iodoacetyl)amino)phenyl]-4-methylcoumarin(DCIA) as potential chemiluminescence with HPLC was reported by Grayeshi and Vasto (35) (see Chemical Structure 2). 

Addition of an alcohol to the amino-substituted disilene 18 proceeds with an even higher regioselectivity than that to the methoxy-substituted disilene 17. Thus, the addition of t-BuOH to 18 is completely regioselective, where only l-diethylamino-l-t-butoxy-2-hydro-l,2,2-trimethyldisilane 33a is obtained. 

CH LORO-9-( ( 4-( DIETHYLAMINO )-l-HETHYLBUTYL ) AMINO )-2-METHOXY-, DIHYDROCHLORIDE, DIHYDRATE RN - 6151-30-0... 

P0D0CARPA-8,11>13-TRIEN-16-OIC ACID, 12-METHOXY- 2-(DIETHYLAMINO )ETHYL ESTER... 

---