Diethylamino group

The kineties of nueleophilie substitution of the methoxy group in methoxy-butenone by the diethylamino group has been studied (91MIl).Thus, the reae-tions of 4-heterobut-3-en-2-ones with amines presented below often involve the transamination step. 

Lidocaine has replaced novocain as the favored anesthetic in dentistry. Both compounds have a tertiary amine group (a diethylamino group) in common. 

The same reaction but with trimethylacetaldehyde results in the frans-adduct exclusively in 100% yield and in 97% ee. The use of the gold catalyst is essential for the high selectivity silver and copper catalysts are much less effective. The length of the side chain between the diethylamino group and the ferrocene nucleus is also an important factor in the selectivity. 

Similarly, the electrooxidation of alcohols carrying a /I-methoxy or f-diethylamino group leads to the corresponding cleavage products in high yields [13]. 

Nucleophilic substitution of chlorine in 2,4-dinitrochlorobenzene by diethylamino group from triethylamine (Scheme 4.18) is a rare example when both the formed opposite-charged ion radicals exist together in the bulk solution for a long time. 

Diethylpropion Diethylpropion, l-phenyl-2-diethylaminopropanon (8.3.6), is synthesized by the bromination of propiophenone into a-bromopropiophenone (8.3.5) and the subsequent substitution of the bromine atom with a diethylamino group [25,26]. 

In compound X the diethylamino group can be exchanged for chlorine when it is reacted with PCl. A mixture of isomers of Xlla and Xllb was observed. 

In a similar way the diethylamino group in the reaction product of N,N -dimethylurea and tris(diethylamino) phosphane, compound XIII (6), was reacted with PCl. The product,however, was compound XIV. 

Chloro(diethylamino)dimethyltin consists of discrete dimer molecules 1, with Sn atoms linked by bridging diethylamino groups. The coordination geometry about the metal atom is a distorted trigonal bipyramid with two C atoms and one N atom in the equatorial plane, and Cl and the second N atom in the axial hypervalent bonding80. 

Two related zinc(II) and magnesium(II) azaphthalocyanines substituted with eight diethylamino groups (compounds 59 and 60) have recently been reported... 

Benzylic amines react with hydrogen peroxide to yield benzaldehydes. For example, 4-bromobenzyl-dimethylamine gives a 60% yield of 4-teomobenzaldehyde. Only six cases were reported, with both di-methylamino and diethylamino groups undergoing the reaction. 

Symmetrical sulfides are obtained in 70-90% yields by refluxing aqueous alcoholic solutions of halides with sodium sulfide. The nonahydrate of sodiiun sulfide is a satisfactory reagent for the reac-tion. Tetramethylene and pentamethylene halides give cyclic sulfides, e.g., tetramethylene sulfide (tetrahydrothiophene) (64%). Halides containing several other important functional groups have been employed. Typical examples include methallyl chloride, and halides with hydroxyl, ethoxyl, carboxyl, and diethylamino groups in the beta position. A dry synthesis of phenyl sulfide from calcium oxide, sulfur, and chlorobenzene at 300° has been reported. ... 

Substituted benzaldehydes and malonic acid give cinnamic acids in excellent yields. Among the common nuclear substituents are methyl, halo, " hydroxyl, methoxyl, " cyano, nitro, and diethylamino groups. Other /fi-arylacrylic acids have been made by the use of a-naphthaldehyde, phenanthraldehydes, and furfural. Phenyl-substituted aliphatic aldehydes have also been used in this condensation. ... 

Problem 4.6 a. This reaction involves loss of the diethylamino group of the amide and ring closure with the aldehyde to form the hydroxylactone product. Because the timing of the ring closure is open to question, two possible mechanistic sequences are given. 

More recently the cyclopropenthione 171 which contains a strongly electron-releasing diethylamino group was shown to have absorptions at 151.76 and 128.56 ppm for C(l) and... 

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