Phosphorus oxychloride, reaction with

Phosphorus oxychloride, reaction with dimethy Iformamide and cyclo hexanone, 46,18... 

The starting material (48-1) for a pyrrazolopyridazine can be obtained by treating the corresponding enol, which is simply the condensation product of methylmaleic anhydride and hydrazine, with phosphorus oxychloride. Reaction with piperazine leads to the displacement of the sterically more accessible chlorine to afford the alkylation product (48-2). Treatment with hydrazine leads to the replacement of the remaining halogen and the formation of (48-3). The missing carbon is, in this case, supplied by formamide to afford zindotrine (48-4) [51], a compound that shows activity as a bronchodilator. 

Phosphine(s), chirality of, 314 Phosphite, DNA synthesis and, 1115 oxidation of, 1116 Phospholipid, 1066-1067 classification of, 1066 Phosphopantetheine, coenzyme A from. 817 structure of, 1127 Phosphoramidite, DNA synthesis and, 1115 Phosphoranc, 720 Phosphoric acid, pKa of, 51 Phosphoric acid anhydride, 1127 Phosphorus, hybridization of, 20 Phosphorus oxychloride, alcohol dehydration with. 620-622 Phosphorus tribromide, reaction with alcohols. 344. 618 Photochemical reaction, 1181 Photolithography, 505-506 resists for, 505-506 Photon, 419 energy- of. 420 Photosynthesis, 973-974 Phthalic acid, structure of, 753 Phthalimide, Gabriel amine synthesis and, 929... 

Title compounds 979 were prepared (75ZC219) by cyclizing 978, prepared by hydrolysis of 977, with phosphorus oxychloride. Reaction of 979 with isobutylamine gave triazolo[5,l-c]triazine 980 (Scheme 181). 

The conversion of 166 to 167 (Scheme 45) most likely involves initial acylation of an N-oxide function. Interestingly, 63 (but perhaps the authors meant 65) did not show typical A-oxide reactions either with phosphorus oxychloride or with acetic anhydride. ... 

Phosphorus oxychloride reacts with l,2-dithiol-3-ones, giving 3-chloro-l,2-dithiolium ions. If this reaction is carried out in the presence of an active methylene compound, a condensation follows immediately, giving a dithiolylidene derivative. For instance, 5-phenyl-l,2-dithiol-3-one reacts with phosphorus oxychloride and benzoylacetonitrile, giving benzoyl-(5-phenyl-l,2-dithiol-3-ylidene)-acetonitrile (Eq. 10).29... 

Enzymatic phosphorylation by phosphorylases and phosphatases produces phosphoesters such as phosphoserine and phosphothreonine. Chemical phosphorylation of proteins changes their functional properties, improving them sometimes (Yoshikawa et al., 1981 Hirotsuka et al., 1984 Huang and Kinsella, 1986 Chobert etal, 1989 Matheis, 1991). However, the properties of the phosphorylated proteins depend entirely on the degree of denaturation and substitution defined by the reaction conditions and the protein (Medina etal, 1992 Sitohy etal, 1994). Casein was phosphorylated by the commonly used methods, characterized by use of excessive amounts of phosphorus oxychloride and with important additions of concentrated inorganic bases (Matheis et al, 1983 Medina et al, 1992). Thus, obtained phosphorylated caseins were highly cross-linked and partially insoluble and difficult to characterize. Hence, there arose a need to produce monomeric over-phosphorylated caseins more suitable for use and for study of their... 

Halogenation of the imidazo[4,5-6]pyridine 4-oxides has provided some interesting results. Treatment of compound (123 R = H) with phosphorus oxychloride gave, with loss of the /v-oxide group, a mixture of the 5-chloro (124) and 7-chloro (125) isomers in comparable amounts in an overall 74% yield (Equation 3) <82JHC513>. The reaction of 3-methylimidazo[4,5-6]pyridine 4-oxide (123 R = CH3) with phosphorus oxychloride also gave a mixture of products but the yields were different, i.e. 5-chloro (124) (20%) and 7-chloro (125) (41%). However, with l-methylimidazo[4,5-6]pyridine 4-oxide (126), the chlorine atom was introduced exclusively into the more sterically hindered 7 position to give the 7-isomer (127). None of the 5-isomer was detected in this reaction (Equation (4)). 

Preparation of Benzenesulphonyl Chloride (SECTION 473).—Convert all of the salt of benzenesulphonic acid obtained in experiment 173 above into benzenesulphonyl chloride as follows HOOD. Place the dry salt in a flask and add phosphorus pentachloride, which should be weighed in the hood, in the proportion of 3 parts by weight of the salt to 4 parts by weight of the chloride. Heat the mixture on the steam-bath, with occasional shaking, for half an hour. Cool, and add to the liquid about ten times its volume of ice-water. Shake about every 10 minutes in order to facilitate the reaction of the phosphorus oxychloride present with water. At the end of an hour... 

Reaction with phosphorus oxychloride or with acetic anhydride leads to the formation of 2-chloro- or... 

Thiocoumarin reacts with phenylmagnesium bromide to give a mixture of 2-phenyl-A -thiochromene and thioflavone, the latter product being presumed to arise by oxidation of 4-hydroxy-2-phenyl-A -chromene, formed via a thiopyrylium cation. 4-Hydroxythiocoumarin has been acetylated at the 3-position, by treatment with acetic acid and phosphorus oxychloride reactions of the product with amines and with phenylhydrazine have been studied. ... 

Gleu, K. Schubert, A. Reaction of phosphorus oxychloride-acridones with Grignard reagents. Ber. Dtsch. Chem. Ges. 1940,73B, 805-811 Chem. Abstr. 1941, 35, 20344. 

The reaction with oxygen converts phosphorus trichloride to phosphorus trichloride oxide (oxychloride), POCI3 the trichloride is able to remove oxygen from some molecules, for example sulphur trioxide... 

Assemble in a fume-cupboard the apparatus shown in Fig. 67(A). Place 15 g. of 3,5-dinitrobenzoic acid and 17 g. of phosphorus pentachloride in the flask C, and heat the mixture in an oil-bath for hours. Then reverse the condenser as shown in Fig. 67(B), but replace the calcium chloride tube by a tube leading to a water-pump, the neck of the reaction-flask C being closed with a rubber stopper. Now distil off the phosphorus oxychloride under reduced pressure by heating the flask C in an oil-bath initially at 25-30, increasing this temperature ultimately to 110°. Then cool the flask, when the crude 3,5-dinitro-benzoyl chloride will solidify to a brown crystalline mass. Yield, 16 g., i.e,y almost theoretical. Recrystallise from caibon tetrachloride. The chloride is obtained as colourless crystals, m.p. 66-68°, Yield, 13 g Further recrystallisation of small quantities can be performed using petrol (b.p. 40-60°). The chloride is stable almost indefinitely if kept in a calcium chloride desiccator. 

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