Quinacrine species

The time-resolved fluorescence spectrum of Quinacrine Mustard at pH 4.6 shows three exponential components whose amplitudes depend on both excitation and observation wavelenghts. This behaviour is tentatively assigned to the formation of three protonated species of the excited molecule. 

Structuie-acdvity relationship studies with mitonafide have revealed that the compound inhibits both nuclear and mitochondrial topoisomerase of Leishmania with preferential taiget-ing of the mitochondrial enzyme over the nuclear enzyme. Anilinoacridines have recently been found to possess andparasidc activity towards Leishmania, Trypanosoma and Plasmodium species. These compounds have been shown to induce protein associated DNA lesions in L. chagasi promastigotes. Linearization of kinteoplast DNA minicirdes have also been repotted in parasites treated with anilinoacridines at similar concentrations. Members of the 9-anilinoacridine topoisomerase II inhibitors have also been shown to inhibit growth of L. major promast otes and amastigotes. 9-aminoacridines, that are reported topoisomerase II inhibitors and structurally related to the antileishmanial compound quinacrine and chlorpro-mazine, have shown anti leishmanial activity at concentrations in the range of 10-20 pM. ... 

Ellison J.R. and Barr H.J. 1971. Differences in the quinacrine staining of the chromosomes of a pair of sibling species Drosophila melanogaster and Drosophila simtdans. Chromosoma 44 424—435. 

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