Coumarin compounds

Synthesis of Triazole and Coumarin Compounds and Their Physiological Activity... 

These observations indicated that an intermolecular double condensation to give a bis N-(methylene-4-oxocoumarinyl)-l,4 aromatic diamine had occurred. Data from the elemental analysis indicated that the calculated and observed values were within the acceptable limits ( 0.4%) and in conformity with the assigned structure. In the addition of molar equivalents of 1,4-aromatic binucleophilic compounds to compound 72 we did not observe any heterocyclic compounds resulting from the further intermolecular nucleophilic attack on the single condensation product. Since the condensation of 3-(dimethylaminomethylene)-chromane-2,4-dione with aromatic binucleophilic compounds is the only route to the new coumarinic compounds, this represents a useful synthetic method. 

Hamdi N, Dixneuf PH (2007) Synthesis of Triazole and Coumarin Compounds and Their Physiological Activity. 10 123-154... 

Higashida, S., Harada, A., Kawakatsu, R., Fujiwara, N., and Matsumura, M. (2006) Synthesis of a coumarin compound from phenanthrene by a Ti02-photocatalyzed reaction. Chemical Communications, (26), 2804-2806. 

Kwakman et al. [65] described the synthesis of a new dansyl derivative for carboxylic acids. The label, N- (bromoacetyl)-A -[5-(dimethylamino)naphthalene-l-sulfonyl]-piperazine, reacted with both aliphatic and aromatic carboxylic acids in less than 30 min. Excess reagent was converted to a relatively polar compound and subsequently separated from the derivatives on a silica cartridge. A separation of carboxylic acid enantiomers was performed after labeling with either of three chiral labels and the applicability of the method was demonstrated by determinations of racemic ibuprofen in rat plasma and human urine [66], Other examples of labels used to derivatize carboxylic acids are 3-aminoperylene [67], various coumarin compounds [68], 9-anthracenemethanol [69], 6,7-dimethoxy-l-methyl-2(lH)-quinoxalinone-3-propionylcarboxylic acid hydrazide (quinoxalinone) [70], and a quinolizinocoumarin derivative termed Lumarin 4 [71],... 

Obidoa O, Obasi SC. 1991. Coumarin compounds in cassava diets 2 health implications of scopoletin in gari. Plant Food for Human Nutrition 41 283-289. 

The reaction of o-cyanobenzyllithium, generated by Te-Li exchange in the corresponding telluride, with aldehydes or ketones followed by acid, promotes lactonization of the obtained hydroxyderivatives, affording 3,4-dihydroiso-coumarins compounds. ... 

Decursinol (18) is a naturally occurring coumarin compound isolated from Angelica gigas (Umbelliferae). In recent studies, two important properties of this compound have been discovered, affecting neuropathology in AD. In one study, mice pretreated with decursinol were able to... 

Eymard s khellin derivatives were dissolved in valproic acid and, following the practice of submitting all such compounds for evaluation in an antiepileptic screening model, they were studied for anticonvulsant activity. These preliminary studies revealed profound anticonvulsant activity. Shortly after this, Meunier serendipitously decided to use valproic acid as a solvent for an unrelated coumarin compound and, although chemically dissimilar to Eymard s khellins, this coumarin exhibited identical anticonvulsant properties. The fact that both compounds had been dissolved in the same solvent was realized immediately. The antiepileptic action of valproic acid was thus discovered completely by accident, with the first successful clinical trial occurring in 1963. 

Chromanones and coumarins, compounds which contain the pyranone ring system, are known to provide plant cells with protection from UV rays. With this in mind, copolymers... 

The fluorescence of coumarin compounds has been well known since 1911, when it was observed that the absorption band of coumarin at 311 nm was bathochromically shifted by one of several auxochromic groups, such as hydroxyl or amino, in the 3- or 7-position. A comparison of the stilbene molecule (88) with 3-phenylcoumarin (93) indicates the similarity of structure, and basically similar substitution patterns in the latter molecule have produced similarly useful FBAs (69FRP1568007). 

Organic anticoagulants are used in vivo in the treatment of numerons conditions where blood coagulation can be dangerous, as in cerebral thrombosis and coronary heart disease, among others which will be described later. The main anticoagulants used are heparin and coumarin compounds, such as warfarin. 

The comparison of three coumarin compounds, 4-(bromomethyl)-7-methoxy-coumarin (Br-MMC), 7-(diethylamino)coumarin-3-carbohydrazide (DCCH), and 7-(diethylamino)-3-[(4-(iodoacetyl)amino)phenyl]-4-methylcoumarin(DCIA) as potential chemiluminescence with HPLC was reported by Grayeshi and Vasto (35) (see Chemical Structure 2). 

The derivatization of DCCH to a carboxylic acid required conversion of the acid to acid chloride using thionyl chloride before reaction with the carbohydrazide group. To evaluate the chemiluminescent characteristics of this coumarin compound, the amide derivative of DCCH was isolated by preparative TLC. Although CL was observed from this product, detection limits were not determined because of the difficulty in quantitative transfer from TLC plates. 

Parts of herb used Flowers and flowering tops. Main actives Volatile oil containing bisabolol compounds, flavonoids, coumarin compounds and mucilages. 

Ekiert, H. and Gomolka, E. (2000) Coumarin compounds in Ammi majus L. callus cultures. Pharmazie, 55, 684-7. 

Superior coumarin compounds separation with use of the described flat sandwich chambers was achieved with gradient chromatography on silica gel and stepwise variation of polar modifier concentration in mobile phase, as less polar solvents (hexane, cyclohexane, toluene, or dichloromethane) and polar modifiers (acetonitrile, diisopropyl ether, ethyl acetate) are used. 

In conclusion, the present study demonstrates that the cytotoxic activity of coumarin derivatives show a strong linear relationship with the absolute hardness, rj. Hardness and softness, apart from the electron accepting and donating properties of the molecule, are important factors for estimation of their cytotoxic activity. From the rj value, the CC50 value of the novel coumarin compounds can be estimated. CONFLEX is useful for calculating the hardness and softness of the molecule using the PM3 method. 

However, both of these libraries were screened only for their inherent fluorescence property, but not tested for their potential as sensors. As envisioned, fluorescence properties such as emission wavelengths and quantium yields of coumarin compounds (Fig. 17.7) in the same library span large diversity. This demonstrated that even a simple substitution on the fluorophore scaffold can dramatically affect the fluorescence properties, which cannot be delicately controlled through a designed approach. A large pool of fluorescent compounds with different properties provided potentially a large platform for screenings on different purposes. 

Nine coumarin compounds Coumarins Angelica gigas Analytical RPC DAD UV, MS 193... 

Pyranocoumarins are class of coumarin compounds. They are rare compounds and only few of them have been investigated. 

It is a well known and often reported fact that individual SCS in molecules with more than one substituent are additive, unless there is an intramolecular interaction between them. This is also mentioned in a number of 13C NMR studies on coumarinic compounds (18, 19, 24, 78, 79). A systematic investigation of the data in this review confirms these findings (see Table 2). 

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