Dietary supplement chemopreventives

Dietary chemoprevention represents an attractive approach to this problem, especially given the yonng age of the patient popnlation. Dietary supplements could be taken orally, which is certaiidy advantageous compared with the daily injections required with interferon therapy or direct injections of the lesions with steroids. Presumably, the side-effect profile would be minimal and certainly much more favorable than the fevers, irritabihty, growth disturbance, immunosuppression, and spastic diplegia (a form of cerebral palsy) associated with the other treatment options discussed in the previous section. Indeed, the EOMA model has proven efficacy to demonstrate the antiangiogenic properties of edible beny extracts and to explore the feasibility of dietary chemoprevention for endothehal cell neoplasms." ... 

Fleshner, N.E. and Kucuk, O., Antioxidant dietary supplements rationale and current status as chemopreventive agents for prostate cancer. Urology, 57, 90-94,2001. 

Khachik, R et al.. Dietary carotenids and their metabolites as potentially useful chemopreventive agents against cancer, in Antioxidant Food Supplements in Human Health, Packer, L., Hiramatsu, M., and Yoshikawa, T., Eds., Academic Press, Tokyo, 1999, p. 203. 

While the epidemiological evidence for a benefit of a range of dietary antioxidants has been corrsistently compelling, the outcome of the large-scale randomized chemoprevention trials employing antioxidant supplement preparatiorrs of vitamin C,... 

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