Dictyostelium

Schroder R R, Jahn W, Manstein D, Hoimes K C and Spudich J A 1993 Three-dimensionai atomic modei of F-actin decorated with Dictyostelium myosin SI Nature 364 171-4... 

Schroeder, R.R., et. al. Three-dimensional atomic model of F-actin decorated with Dictyostelium myosin SI. Nature 364 171-174, 1993. 

Smith, C. A., Rayment, 1. X-ray structure of the magnesium (11). ADP-vanadate complex of the Dictyostelium discoideum myosin motor domain to 1.9 A resolution. Biochemistry 35 5404-5407, 1996. 

Studies in yeasts (Saccharomyces cerevisiae, Schizo-saccharomyces pombe), slime mould (,Dictyostelium discoideum), worm (Caenorhabditis elegans), fly (Drosophila melanogaster) and mammalian systems have all contributed to our understanding of TOR signalling. 

Devreotes, P.N. (1988). Chemotaxis in eukaryotic cells A focus on leukocytes and Dictyostelium. Ann. Rev. Cell Biol. 4, 649-686. 

Fukui, Y., Lynch, T.J., Brzeska, H., Korn, E.D. (1989). Myosin 1 is located at the leading edges of locomoting Dictyostelium amoebae. Nature 341, 328-331. 

The regulation of myosin-I activity is not well understood. As mentioned above, the heavy chain is phosphorylated in Acanthamoeba but the regulatory effect of this process is unclear. Myosin-I from Acanthamoeba, Dictyostelium, brush-bor-... 

De Lozanne, A. Spudich, J.A. (1987). Disruption of the Dictyostelium myosin heavy chain gene by homologous recombination. Science 236, 1086-1091. 

Manstein, D.J., Ruppel, K.M., Spudich, J.A. (1989). Expression and characterization of a functional myosin head fragment in Dictyostelium discoideum. Science 246, 656-658. 

Myosin II Dictyostelium ablated little DeLozanne and Spudich, 1987... 

Sever n Dictyostelium ablated no apparent change Andre et al., 1989... 

A second type of cytokinesis has come to light in mutants of Dictyostelium lacking mysoin-II. These cells are able to crudely separate by traction mediated cytokinesis, a process by which the bi- (or multi-) nucleate cells tear themselves apart in an attempt to crawl in two opposite directions. 

Andre, E., Brink, M., Gerisch, G., Isenberg, G., Noegel, A., Schleicher, M., Segall, J.E., Wallraff, E. (1989). A Dictyostelium mutant deficient in severin, an F-actin fragmenting protein, shows normal motility and chemotaxis. J. Cell Biol. 108, 985-995. 

Knecht, D.A., Loomis, W.F. (1987). Antisense RNA inactivation of myosin heavy chain gene expression in Dictyostelium discoideum. Science 236, 1081-1086. 

Newell, P.C., Europe-Finner, G.N., Small, N.V. (1987). Signal transduction during amoebal chemo-taxis of Dictyostelium discoideum. Microbiol. Sci. 4. 5-11. 

Titus, M.A., Wessels, D., Spudich, J.A., Soli, D. (1993). The unconventional myosin encoded by the myoA gene plays a role in Dictyostelium motility. Mol. Biol. Cell 4,233-246. 

Wallraff, E., Schleicher, M., Modersitzki. M Reiger, D., Isenberg, G., Gerish, G. (1986). Selection of Dictyostelium mutants defective in cytoskeletal protein Use of an antibody that binds to the ends of alpha-actinin rods. EMBO J. 5,61-67. 

Wessels. D., Soil, D.R.. Knecht, D.. Loomis. W.F., De Lozanne. A., Spudich, J. (1989). Myosin IB null mutants of Dictyostelium exhibit abnormalities in motility. Cell Mot. Cytoskel. 20,301-315. 

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