Dictyostelium cells cAMP oscillations

Some of the main examples of biological rhythms of nonelectrical nature are discussed below, among which are glycolytic oscillations (Section III), oscillations and waves of cytosolic Ca + (Section IV), cAMP oscillations that underlie pulsatile intercellular communication in Dictyostelium amoebae (Section V), circadian rhythms (Section VI), and the cell cycle clock (Section VII). Section VIII is devoted to some recently discovered cellular rhythms. The transition from simple periodic behavior to complex oscillations including bursting and chaos is briefly dealt with in Section IX. Concluding remarks are presented in Section X. 

Appendix Model for oscillations and relay of cAMP signals in Dictyostelium cells rednction to a three>variable systemf... 

Goldbeter, A. 1987b. Periodic signaling and receptor desensitization from cAMP oscillations in Dictyostelium cells to pulsatile patterns of hormone secretion. In Temporal Disorder in Human Oscillatory Systems. L. 

Goldbeter, A. J.L. Martiel. 1988. Developmental control of a biological rhythm the onset of cAMP oscillations in Dictyostelium cells. In From Ghemical to Biological Organization. M. Markus, S. Muller G. Nicolis, eds. Springer, Berlin, pp. 248-54. 

Gundersen, R.E., R. Johnson, P. Lilly, G. Pitt, M. Pupillo, T. Sun, R. Vaughan P.N. Devreotes. 1989. Reversible phosphorylation of G-protein-coupled receptors controls cAMP oscillations in Dictyostelium. In Cell to Cell Signalling From Experiments to Theoretical Models. A. Goldbeter, ed. Academic Press, London, pp. 477-88. 

Halloy, J., Y.X. Li, J.L. Martiel, B. Wurster A. Goldbeter. 1990. Coupling chaotic and periodic cells results in a period-doubling route to chaos in a model for cAMP oscillations in Dictyostelium suspensions. Phys. Lett. A. 151 33-6 cmd (Erratum) 159 442 (1991). 

The three best-known examples of biochemical oscillations were found during the decade 1965-1975 [40,41]. These include the peroxidase reaction, glycolytic oscillations in yeast and muscle, and the pulsatile release of cAMP signals in Dictyostelium amoebae (see Section V). Another decade passed before the development of Ca " " fluorescent probes led to the discovery of oscillations in intracellular Ca +. Oscillations in cytosolic Ca " " have since been found in a variety of cells where they can arise spontaneously, or after stimulation by hormones or neurotransmitters. Their period can range from seconds to minutes, depending on the cell type [56]. The oscillations are often accompanied by propagation of intracellular or intercellular Ca " " waves. The importance of Ca + oscillations and waves stems from the major role played by this ion in the control of many key cellular processes—for example, gene expression or neurotransmitter secretion. 

Dealt with in turn are (i) glycolytic oscillations that occur in yeast and muscle cells, with a period of several minutes (ii) oscillations of cyclic AMP (cAMP) that govern with a similar period the transition from the unicellular to the multicellular stage in the life cycle of Dictyostelium amoebae (iii) intracellular Ca oscillations, which occur with a period ranging from seconds to minutes in many cell types, either spontaneously or after stimulation by a hormone or a neurotransmitter ... 

---