Dictyostelium discoideum cAMP stimulation

Dinauer, M., T.L. Steck P.N. Devreotes. 1980c. Cyclic 3, 5 AMP relay in Dictyostelium discoideum. V. Adaptation of the cAMP signaling response during cAMP stimulation. J. Cell Biol 86 554-61. 

The results obtained by Wurster (1982) in Dictyostelium and by Knobil (1980) in the rhesus monkey show, nevertheless, that the frequency of stimulation is as important as the periodic nature of the signal in eliciting an adequate response. The results shown in fig. 8.1 obtained from the model for cAMP synthesis based on receptor desensitization in D. discoideum provide a theoretical basis for these observations. Confirming that the efficiency of the signal is a function of its frequency, these results suggest that the optimum frequency will be dictated by the relative values of the interval between successive stimuli and the time required for receptor resensitization. 

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