Dictyostelium cells

J. L. Martiel and A. Goldbeter, A model based on receptor desensitization for cychc AMP signaling in Dictyostelium cells. Biophys. J. 52, 807-828 (1987). 

Y. X. Li and A. Goldbeter, Erequency encoding of pulsatile signals of cyclic AMP based on receptor desensitization in Dictyostelium cells. J. Theor. Biol. 146, 355-367 (1990). 

S. Sawai, P. A. Thomason, and E. C. Cox, An autoregulatory circuit for long-range self-organization in Dictyostelium cell populations. Nature 433, 323-326 (2005). 

Ravid, S. Spudich, J.A. Myosin heavy chain kinase from developed Dictyostelium cells. Purification and characterization. J. Biol. Chem., 264, 15144-15150 (1989)... 

Nagasaki, A. Itoh, G. Yumura, S. Uyeda, T.Q. Novel myosin heavy chain kinase involved in disassembly of myosin II filaments and efficient cleavage in mitotic dictyostelium cells. Mol. Biol. Cell, 13, 4333-4342 (2002)... 

Van Dijken, P., Bergsma, J.C. and Van Haastert, P.J.M., 1997, Phospholipase C-independent inositol 1,4,5-trisphosphate formation in Dictyostelium cells. Activation of a plasma-membrane-bound phosphatase by receptor-stimulated Ca2+ influx. Eur. J. Biochem. 244 113-119. 

Ma L, Janetopoulos C, Yang L, Devreotes PN, Iglesias PA. Two complementary, local excitation, global inhibition mechanisms acting in parallel can explain the chemoattractant-induced regulation of PI(3,4,5)P3 response in Dictyostelium cells. Biophys. J. 2004 87 3764-3774. 

Aizawa H, Katadae M, Maniya M et al. Hyperosmotic stress-induced reorganization of actin bundles in Dictyostelium cells over-expressing cofilin. Genes Cells 1999 4(6) 311-324. 

Etzrodt M, Ishikawa FlC, Dalous J et al. Time-resolved responses to chemoattractant, characteristic of the front and tail of Dictyostelium cells. FEES Lett 2006 580(28-29) 6707-13. 

Heterogeneity in the kinetic states of signaling molecules was also found in ligand binding reactions in chemotaxing Dictyostelium cells [45]. Dictyostelium cells exhibit chemotaxis in response to cyclic adenosine 3, 5 -monophosphate (cAMP). Dictyostelium cells move randomly in the absence of a cAMP concentration gradient. In the presence of a gradient, however, movement is... 

The transition from unicellular to multicellular growth is triggered by cell-cell communication and reveals much about signaling processes between and within cells. Under starvation conditions, Dictyostelium cells release the signal molecule cyclic AMP. This molecule signals surrounding cells by binding to a membrane-bound protein receptor on the cell surface. 

Appendix Model for oscillations and relay of cAMP signals in Dictyostelium cells rednction to a three>variable systemf... 

With respect to the possible occurrence of chaos in Dictyostelium cells, the present results provide one plausible explanation for the occurrence of rather regular oscillations in suspensions of the putatively... 

As explained at the end of this chapter, although specifically formulated for the case of Dictyostelium cells, the ideas presented below generalize to other biological systems in which dynamic properties such as excitable or oscillatory behaviour arise in the course of development. 

That the random pulsatile signal is less effective than the periodic one accounts for the observations of Nanjundiah (1988), who studied the effect of random cAMP signals in Dictyostelium by varying the interpulse interval from 0 to 10 min in a stochastic manner. These experiments indicated that, like constant cAMP stimuli or cAMP pulses delivered at 2 min intervals (Wurster, 1982), the random cAMP signal fails to induce differentiation in Dictyostelium cells, in contrast to cAMP pulses delivered at 5 min intervals (Gerisch etal, 1975). 

Gerisch, G. B. Hess. 1974. Cyclic-AMP controlled oscillations in suspended Dictyostelium cells their relation to morphogenetic cell interactions. Proc. Natl. Acad. ScL USA 71 2118-22. 

Gerisch, G., D. Malchow, W. Roos U. Wick. 1979. Oscillations of cycUc nucleotide concentrations in relation to the excitability of Dictyostelium cells. J. Exp. Biol. 81 33-47. 

Gerisch, G. U. Wick. 1975. Intracellular oscillations and release of cyclic AMP from Dictyostelium cells. Biochem. Biophys. Res. Commun. 65 364-70. 

Goldbeter, A. 1987b. Periodic signaling and receptor desensitization from cAMP oscillations in Dictyostelium cells to pulsatile patterns of hormone secretion. In Temporal Disorder in Human Oscillatory Systems. L. 

Goldbeter, A. J.L. Martiel. 1988. Developmental control of a biological rhythm the onset of cAMP oscillations in Dictyostelium cells. In From Ghemical to Biological Organization. M. Markus, S. Muller G. Nicolis, eds. Springer, Berlin, pp. 248-54. 

Guidi, G.M., J. Halloy A. Goldbeter. 1995. Chaos suppression by periodic forcing Insights from Dictyostelium cells, from a multiply regulated biochemical system, and from the Lorenz model. In Chaos and Complexity. J. Trfin Thanh Vin et al, eds. Editions Frontieres, Gif-sur-Yvette, France, pp. 135-46. 

Li, Y.X., J. Halloy, J.L. Martiel A. Goldbeter. 1992a. Suppression of chaos and other dynamical transitions induced by intercellular coupling in a model for cAMP oscillations in Dictyostelium cells. Chaos 2 501-12. 

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