Diazepam interaction

Admixture incompatibility- Do not mix or dilute with other solutions or drugs in syringe or infusion flask. Diazepam interacts with plastic containers and administration sets, significantly decreasing availability of drug delivered. 

Clonazepam As for diazepam >80% bioavailability extensively metabolized but no active metabolites fiy2 20-50 h Absence seizures, myoclonic seizures, infantile spasms Toxicity Similar to diazepam Interactions Minimal... 

Wali FA. Myorelaxant effect of diazepam. Interactions with neuromuscular blocking agents and cholinergic drugs. Acta Anaesthesiol Scand 1985 29(8) 785-9. 

Murphy A, Wilbur K. Phenytoin-diazepam interaction. Ann Pharmacother 2003 37 659-63. 

Ochs HR, Greenblatt DJ, Roberts GM, Dengler HJ. Diazepam interaction with antituberculosis drugs. Clin Pharmacol Ther 1981 29(5) 671-8. 

Dhillon S, Richens A. Valproic acid and diazepam interaction in vivo. BrJ Clin Pharmacol (1982) 13, 553-60. 

Valerian Valeriana officinalis Restlessness, sleep disorders Rare if used as directed. May interact with the barbiturates (eg, phenobarbital), the benzodiazepines (eg, diazepam) and the opiates, (eg, morphine). 

While generally not of major concern, omeprazole may inhibit the metabolism of warfarin, diazepam, and phenytoin lansoprazole may decrease theophylline concentrations. Drug interactions with omeprazole are of particular concern in patients who are considered slow metabolizers, as are approximately 3% of the Caucasian population. Unfortunately, it is unclear which patients have the polymorphic gene variation that makes them slow metabolizers.17 The metabolism of esomeprazole may also be altered in patients with this polymorphic gene variation. Patients on potentially interacting drugs should be monitored for development of drug-related problems. 

I with seizures and require anticonvulsant therapy. Phenytoin is the most frequently used agent, with a loading dose of 15 mg/kg followed by 300 mg by mouth daily (titrated to therapeutic levels between 10 and 20 mcg/mL). Diazepam 5 mg intravenously may be used for rapid control of persistent seizures. Prophylactic anticonvulsants have been used frequently, but a recent meta-analysis did not support their use.23 Thus, because adverse effects and drug interactions are common, the routine use of prophylactic anticonvulsants is not recommended. 

Roache, J. and Griffiths, R., Interaction of diazepam and caffeie Behavioral and subjective dose effects in humans. Pharmacology, Biochemistry and Behavior 26(4), 801-812, 1987. 

Commissaris, R. L., and Rech, R. H. (1982) Interactions of metergoline with diazepam, quipazine, and hallucinogenic drugs on a conflict behavior in the rat. Psychopharmacology, 76 282-285. 

Chermat R, Brochet D, DeFeudis FV, Drieu K. (1997). Interactions of Ginkgo biloba extract (EGb 761), diazepam and ethyl beta-carboline-3-carboxylate on social behavior of the rat. Pharmacol Biochem Behav. 56(2) 333-9. 

The disinhibitory effects of 5-HT3 receptor antagonists are now well documented [29, 30]. These compounds act to restore normal behaviour to animals in conditions which are mildly aversive, such as a novel brightly lit test area. Such effects may be predictive of anxiolytic activity. An example of such disinhibition is the effect of ondansetron in the rat social interaction test in which the level of interaction between two rats is measured under certain defined conditions [29]. In non-aversive conditions this type of behaviour is quite marked, but it is suppressed in novel highly illuminated conditions. Ondansetron overcomes this suppression, as do known anxiolytics such as diazepam. 

Possible interactions with Amitriptyline Diazepam Antipsychotics Astemizole... 

Diazepam (Valium, Diastat) [C-IVj [Anxiolytic, Skeletal Muscle Relaxant, Anticonvulsant, Sedative/Hypnotic/ Benzodiazepine] Uses Anxiety, EtOH withdrawal, muscle spasm, status epilepticus, panic disorders, amnesia, preprocedure sedation Action Benzodiazepine Dose Adults. Status epilepticus 5-10 mg IV/IM Anxiety 2-5 mg IM/IV Preprocedure 5-10 mg IV just prior to procedure Peds. Status epilepticus 0.5-2 mg IV/IM Sedation 0.2-0.5 mg/kg IV (onset w/in 5IV and 30 min IM duration about 1 h IV and IM) Caution [D, / -] Contra Coma, CNS depression, resp d es-sion, NAG, severe uncontrolled pain, PRG Disp Tabs 2, 5, 10 mg soln 1, 5 mg/mL inj 5 mg/mL rectal gel 2.5, 5, 10, 20 mg/mL SE Sedation, amnesia, bradycardia, i BP, rash, X resp rate Interactions T Effects W/ antihistamines, azole antifungals, BBs, CNS depressants, cimetidine, ciprofloxin, disulfiram, INH, OCP, omeprazole, phenytoin, valproic acid, verapamil, EtOH, kava kava, valman T effects OF digoxin, diuretics X effects w/ barbiturates, carbamazepine. 

Ciprofloxacin (Cipro, Cipro XR, Proquin XR) [Antibiotic/ Fluoroquinolone] Uses Rx lower resp tract, sinuses, skin skin structure, bone/joints, urinary tract Infxns including prostatitis Action Quinolone antibiotic DNA gyrase Dose Adults. 250-750 mg PO ql2h XR 500-1000 mg PO q24h or 200-400 mg IV ql2h in renal impair Caution [C, /-] Children <18 y Contra Component sensitivity Disp Tabs, susp, inj SE Restlessness, N/V/D, rash, ruptured tendons, T LFTs Interactions T Effects Wf probenecid T effects OF diazepam, theophylline, caffeine, metoprolol, propranolol, phenytoin, warfarin effects W/ antacids, didanosine, Fe salts. Mg, sucralfate, Na bicarbonate,... 

PO H. pylori Infxn 40 mg/d PO, plus clarithromycin 500 mg PO bid amoxicillin 1000 mg bid for 10 d Caution [B, /-] Contra Component sensitivity Disp Caps, IV SE HA, D, abd pain Interactions t Effects W7 amoxicillin, clarithromycin T effects OF benzodiaz ines, warfarin X effects OF digoxin, keto-conazole, iron salts EMS Use caution w/ diazepam, may t risk of diazepam tox OD May cause sweating, blurred vision, tach, and confusion symptomatic and supportive... 

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