Phenytoin diazepam

Goal Time to Diazepam + phenytoin 9 minutes hypotension, and ... 

In cases of lead encephalopathy with cerebral edema, edema can be treated with mannitol, corticosteroids, and hypothermia. Convulsions can be treated with diazepam, phenytoin, and/or phenobarbital (Garrettson 1990). 

Omeprazole can inhibit the metabolism of drugs metabolised mainly by the cytochrome P-450 enzyme subfamily 2C (diazepam, phenytoin), but not of those metabolished by subfamilies lA (caffeine, theophylline), 2D (metoprolol, propranolol), and 3A (ciclosporin, lidocaine (lignocaine), quinidine). Since relatively few drugs are metabolised mainly by 2C compared with 2D and 3A, the potential for omeprazole to interfere with the metabolism of other drugs appears to be limited, but the half lives of diazepam and phenytoin are prolonged as much as by cimetidine. 

Among the various other types of epilepsy are partial seizures which involve some involuntary muscle spasm or sensual disturbance without loss of consciousness. Phenobarbital, diazepam, phenytoin and carbamazepine are the most commonly used medications for this condition. As... 

Short-term management of insomnia Action Benzodiazepine Dose 1-2 mg PO qhs PRN X in hepatic impair/elderly/debilitated Caution [X, -] T Effects w/ CNS depressants Contra PRG Disp Tabs SE Somnolence, weakness, palpitations, anaphylaxis, angioedema, amnesia Interactions T Effects W/ amoxicillin, clarithromycin T effects OF diazepam, phenytoin, warfarin X effects W/ food X effects OF azole antifungals, digoxin EMS Use caution w/ other benzodiazepines, may need a reduced dose concurrent EtOH and caffeine use can T CNS effects OD May cause altered reflexes, drowsiness, CNS depression, slurred speech, and Szs flumazenil can be used as an antidote... 

C19. V-Mcphenyloin, diazepam, phenytoin, omeprazole, indomethacin, impramine, propanolol, proguanil [S-Mephentoin (4 -OH)]... 

Drugs in Table 3-1 that are poorly extracted by the liver include chlorpropamide, diazepam, phenytoin, theophylline, tolbutamide, and warfarin. 

May increase piasma ieveis of drugs metaboiized by CYP450 2C19 (e.g., diazepam, phenytoin, propranoioi)... 

Drugs that exhibit the hepatic first-pass phenomenon do so because of the rapidity with which they are metabolised. The rate at which drug is delivered to the liver, i.e. blood flow, is then the main determinant of its metabolism. Many other drugs are completely metabolised by the liver but at a slower rate and consequently loss in the first pass through the liver is unimportant. The parenteral dose of these drugs does not need to be reduced to account for presystemic elimination. Such drugs include diazepam, phenytoin, theophylline, warfarin. 

Diazepam Phenytoin Interaction inconsistent, usually of no clinical significance Inhibition of phenytoin metabolism... 

Cimetidine Carbamazepine Clobazam Clonazepam Diazepam Phenytoin Valproate Risk of toxicity, particularly with phenytoin Inhibition of metabolism of the object drugs... 

Ethanol Clobazam Diazepam Phenytoin Risk of toxicity of the object drugs chronic ethanol can reduce serum phenytoin concentrations Inhibition of metabolism induction of phenytoin metabolism by chronic ethanol... 

A 32-year-old man, who had been in hospital for several months because of acute intermittent porphyria and chronic pancreatitis, had a seizure and an asystolic cardiac arrest. Resuscitation was unsuccessful. There was a suspicion of patient mistreatment by one of the attending nurses, and toxicological analyses showed high blood concentrations of lidocaine, diazepam, phenytoin, and promethazine. Diazepam and phenytoin... 

Atropine sulfate is the drug of choice. Epinephrin may assist in overcoming severe cardiovascular or bronchoconstriction. Diazepam, phenytoin, and phe-nobarbital may be given in cases of seizures. Induction of emesis is not necessary due to spontaneous vomiting. Activated charcoal slurry with or without... 

Proton pnmp inhibitors Omeprazole Lansoprazole Pantoprazole Antiepileptics Diazepam Phenytoin Phenobarbitone Amitriptyline Clomipramine Cyclophosphamide Progesterone... 

Status epllepticus Lorazepam, diazepam, phenytoin, or fosphenytoin Phenobarbital (long term)... 

May cause mild CNS and GI effects and 1 bioavailability of drugs that require acidity for oral absorption (e.g., fluoroquinolones, ketoconazole). Inhibit P450 — >L elimination of diazepam, phenytoin, and warfarin. 

Competitive inhibition caused by two drugs competing for the binding site in the enzyme, e.g., (jSi)-omeprazole inhibiting the oxidation of diazepam, phenytoin, or (JR)-warfarin. 

Inhibit P450 —>4- elimination of diazepam, phenytoin, and warfarin... 

A. Pentobarbital is used for the management of status epilepticus that is unresponsive to conventional anticonvulsant therapy (eg, diazepam, phenytoin, or phenobarbital). If the use of pentobarbital for seizure control is considered, consultation with a neurologist is recommended. 

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