Methyl methacrylate-dextran

DDMC 2-Diethyl-aminoethyl-dextran-methyl methacrylate graft copolymer... 

Onishi Y, Eshita Y, Murashita A et al (2005) Synthesis and characterization of 2-diethyl-aminoethyl-dextran-methyl methacrylate graft copolymer for nonviral gene delivery vector. J Appl Polym Sci 98 9-14... 

STUDY OF DEXTRAN-METHYL METHACRYLATE GRAFT COPOLYMER... 

Onishi, Y. Maruno, S. Kamiya, S. Hokkoku, S. Hasegawa, M. (1978).Preparation and characteristics of dextran-methyl methacrylate graft eopoly-mer. Polymer,19, 325- 3>2%. 

Chapter 9 - 2-diethylaminoethyl(DEAE)-Dextran is still an important substance for transfection of nucleic acids into cultured mammalian cells by the reason of its safety owing to autoclave sterilization different from lipofection vectors. However, DEAE-Dextran may not be superior to lipofection vectors with cytotoxic and a transfection efficiency. A stable soap-less latex of 2-diethylaminoethyl(DEAE)-Dextran-methyl methacrylate( MMA) graft eopolymer (DDMC) of a high transfection activity has been developed as Non-viral gene delivery vectors possible to autoclave at 121 for 15 minutes.Transfection activity determined by the X-gal staining method show a higher value of 50 times or more for DDMC samples... 

Avseenko et al. (2001) immobilized antigens onto aluminum-coated Mylar films by electrospray (ES) deposition. Various surface modifications of the metallized films were studied to determine their abilities to enhance sensitivity. The plastic surfaces were firsf cleaned by plasma discharge treatment, followed by coating with proteins (BSA and casein) or polymers such as poly (methyl methacrylate) or oxidized dextran, or they were exposed to dichlorodimethyl silane to create hydrophobic surfaces. Protein antigen was prepared in 10-fold excess sucrose and sprayed onto the surfaces to form arrays with spot diameters between 7 and 15 pm containing 1 to 4 pg protein. 

Passirani, C., L. Ferrarini, et al. (1999). Preparation and characterization of nanoparticles bearing heparin or dextran covalently-linked to poly(methyl methacrylate). J Biomater Sci Polym Ed 10(1) 47-62. 

There is a limited number of polymers for which narrow MWD standards are commercially available polystyrene, poly(methyl methacrylate), poly(a-methyl styrene), polyisoprene, polybutadiene, polyethylene, poly(dimethyl siloxane), polyethyleneoxide, pullulan, dextran, polystyrene sulfonate sodium salt, and globular proteins. In some cases, the standards available cover a limited molecular weight range, so it may be impossible to construct the calibration curve over the complete column pore volume. 

Passirani C, Barratt G, Devissaguet J-P, et al. (1998). Interactions of nanoparticles bearing heparin or dextran covalently bound to poly(methyl methacrylate) with the complement system. Life Sci. 62 775-785. 

Methyl methacrylate (mMA) was graft pol3nnerized onto dextran in the presence of Ce " " salts. The resulting polymer is neither soluble in water, an excellent solvent for dextran, nor in acetone, an excellent solvent for poly-(methyl methacrylate) (PMMA). A hot-pressed film of the copol3mier not only showed better wettability and water absorbing power than PMMA but also thromboresistance. There was also correlation like matrix mechanism between the molecular weight of the reactant dextran and that of the branch PMMA in the product. 

Graft copolymer of A -vinylpyrrolidone with such polymers as dextran, poly(acrylate esters), polyacrylonitrile, polytetrafluoroethylene, poly(methyl methacrylate) films, polyester films, and polyolefins have been reported [24]. 

For example, this method was carried out for various copolymers, namely styrene-methyl methacrylate copolymer [65-67], epoxide resins [68], styrene-acrylic acid copolymer [69], styrene-2-methoxyethyl methacrylate copolymer [70, 71], ethylene-ot-olefin copolymer [72], partially modified dextran-ethyl carbonate copolymer [73], vinyl chloride-vinyl acetate copolymer [43], styrene-acrylonitrile copolymer [74], and styrene-butadiene copolymer [75]. 

Entrapment within polyacrylamide beads Reaction with cyanogen bromide-treated copolymers of acrylamide and 2-hydroxyethyl methacrylate Reaction with glutaraldehyde-treated polyacrylamide and with copolymers of acrylamide and methyl methacrylate Reaction with glutaraldehyde-treated polyacrylamide beads Coating on a platinum electrode and enclosure within nylon netting Hydrophobic interaction with cellulose esters and with phenoxyacetylated-dextran and other derivatives of glass... 

---