Dexamfetamine Alcohol

Interactions. Morphine (also pethidine and possibly other opioids) is potentiated by monoamine oxidase inhibitors. Any central nervous system depressant (including alcohol) will have additive effects. Patients recently exposed to neuromuscular blocking agents (unless this is adequately reversed, e.g. by neostigmine) are particularly at risk from the respiratory depressant effects of morphine. The effect of diuretic drugs may be reduced by release of antidiuretic hormone by morphine. Useful interactions include the potientating effect on pain relief of tricyclic antidepressants and of dexamfetamine. 

Dexamfetamine can reduce the deleterious effects of alcohol to some extent, but some impairment still occurs making it unsafe to drive. Another report su ests the combination of metamfeta-mine and alcohol produces an increase in perceived total intoxication, and may also increase cardiac adverse effects. 

In 12 healthy subjects alcohol 0.85 g/kg (2 mL/kg of 100 proof vodka in orange juice) worsened the performance of a SEDI task (Simulator Evaluation of Drug Impairment). This task is believed to parallel the skills needed to drive safely, and involves tests of attention, memory, recognition, decision making and reaction times. When the subjects were al so given dexamfetamine 90 or 180 micrograms/kg, there was a dose-related improvement in the performance of the SEDI task, but the subjective as-... 

Earlier reports using different testing methods found that in some tests dexamfetamine modified the effects of alcohol, but the total picture was complex. Other reports found no antagonism. Another study found that in stress situations, where relief of fatigue or boredom alone will not produce improved performance, dexamfetamine failed to improve attentive motor performance impaired by alcohol. A later study found that, while the combination of alcohol and metamfetamine diminished the subjective feelings of alcohol intoxication, there was actually an increase in feelings of total intoxication. The combination of alcohol and metamfetamine may increase cardiac toxicity. ... 

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See also in sourсe #XX -- [ ]

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