Desquamation

Soap as used in personal cleansing products has a long safe history of use. Modem soaps have been specifically formulated to be compatible with skin and to be used on a daily basis with minimal side effects. Excessive use of soap for skin cleansing can dismpt the natural barrier function of skin through the removal of skin oils and dismption of the Hpid bdayer in skin. This can result in imperfect desquamation or a dry appearance to skin and cause an irritation response or erythema, ie, reddening of the skin. Neither of these is a permanent response and the eHcitation of this type of skin reaction depends on the individual s skin type, the product formulation, and the frequency of use. 

Abblasehahn, m. blowoff cock, abblasen, v.t. blow away, blow off, blow blast (castings) distil off. — v.i. (of gases) expand. Abblaseventil, n. blowoff valve, abblassen, v.i. fade, lose color, grow pale, abblattem, v.r. i. scale off, exfoliate desquamate shed the leaves. — v.t. descale strip of leaves. 

Hautung, /. skinning shedding of the skin, desquamation, molting. 

Schalung, /. casing, sheathing, form. Schklung,/. shelling, etc, (see schalen) excoriation, desquamation. 

Sodium dodecyl sulfate has been used to induce a dry, scaly skin condition in human subjects by daily treatment with a 4% aqueous solution on one leg over a period of 2 weeks. Measurements were made of stratum comeum hydration, scaliness, and lipid composition which were used to assess in vivo surfactant perturbations on desquamation [381]. 

GB Acnezide (Galderma) ltalchimici)-comb. Desquam-E (Westwood-... 

Increased desquamation in some patients lasting up to 7-10 days... 

It is a lipophilic compound which removes intercellular lipids that are covalently linked to the cornified envelope surrounding epithelial cells [3]. It also enhances penetration of other agents. Resorcinol (m-dihydroxy benzene) is structurally and chemically similar to phenol. It disrupts the weak hydrogen bonds of keratin [4]. Lactic acid is an alpha hydroxy acid which causes corneocyte detachment and subsequent desquamation of the stratum corneum [5]. 

Very mild erythema Mild desquamation Short post-operative period... 

Salicylic acid (ortho hydroxybenzoic add) is a beta hydroxy acid agent. It is a lipophilic compound which produces desquamation of the stratum corneum via removal of intercellular lipids [3] (see salicylic acid section). Given its keratolytic effects, it has become an increasingly popular superficial peeling agent. Salicylic acid peels induce injury via thinning or removal of the stratum corneum. In addition, salicylic acid potentially enhances the penetration of TCA. 

Generally used at a concentration of 0.05-1% with minimal side effects (erythema and desquamation), retinoic acid has to be applied once a day, usually nightly. It does not suppress melanogenesis, but accelerates epidermal turn-... 

Although riboflavin is fundamentally involved in metabolism, and deficiencies are found in most countries, it is not fatal as there is very efficient conservation of tissue riboflavin. Riboflavin deficiency is characterized by cheilosis, lingual desquamation and a seborrheic dermatitis. Riboflavin nutritional status is assessed by measurement of the activation of erythrocyte glutathione reductase by FAD added in vitro. 

Erythrodermic psoriasis is a generalized, life-threatening condition that presents with erythema, desquamation, and edema, and may require life support measures as well as systemic therapy. 

---