Designer dmgs

MACCS-II enables direct interface with other database management systems, such as the Relational Database Management System (RDBMS) and Oracle, so that databases which contain text and numeric data for which special interfaces are normally needed can be constmcted. Eor example, an Oracle MACCS-II linked system is currendy being used by the National Institute on Dmg Abuse (113) to develop a database that will allow scientists to determine the molecular stmctures of cocaine and other controlled substances as well as designer dmgs. 

The aim of this book is to provide a conceptual framework for medicinal chemistry. Chapter 1 dealt with the properties necessary to transform a molecule into a drug-like molecule. Chapter 2 described the properties that determine whether a macromolecule could be a receptor. It is now necessary to develop a method of designing dmg molecules to fit into receptor molecules. The multiphore method of dmg design is such a method. 

Arnold E, Das K, Ding J, Yadav PNS, Hsiou, Y, Boyer PL, Hughes SH. Targeting HIV reverse transcriptase for anti-AIDS dmg design. Dmg Design and Discovery 1996 13 29-47. 

The Controlled Substance Analogue Dmg Bill. This is contained within Public Law 99-570, the Controlled Substances Analogue Enforcement Act of 1986. This is the so-called Designer Dmg bill which was intended to allow the prosecution of any act associated with an unscheduled dmg, if that drug is analogous either in structure or in action to a scheduled dmg, and if it is intended for use in man. Here is the exact wording of this amendment ... 

Flabrdova, V., Peters, F.T., Theobald, D.S., Maurer, H.FI. Screening for and validated for quantification of phenethylamine-type designer dmgs and mescaline in human blood plasma by gas chromatography/mass spectrometry. J. Mass Spectrom. 40, 785-795 (2005)... 

Kraemer T and Maurer HH (2002) Toxicokinetics of amphetamines Metabolism and toxicokinetic data of designer dmgs, amphetamine, methamphetamine and their N-alkyl derivatives. Therapeutic Drug Monitoring 24(2) in-im. 

Carr, R., Congreve, M., Murray, C., Rees, D. Eragment-based lead discovery leads by design. Dmg Discov. Today 2005,10, 987—992. 

The goal of chemotherapy is to exploit a biochemical difference between the disease process and the host tissue in order to interfere selectively with the disease process. Knowledge from x-ray crystallographic analysis of enzymes and molecular modeling with modem computer software allows scientists to design dmgs that fit into important, specific regions of enzymes (such as the active site) and inactivate them. 

Lit Harvey, Marihuana 84, p. 37, Oxford IRL Press 1985. gen. J. Forensic Sci. 33, 1385 (1988) Nature (London) 346, 561 (1990) Redda, Walker Bamell, Cocaine, Marijuana, Designer Dmgs Chemistry, Pharmacology and Behavior, Boca Raton CRC Press 1989. 

Liquid-liquid or solid-phase procedures for extraction are predominant in the determination of amphetamines, methamphetamines, and other designer dmgs in blood and urine. Following the extraction, the derivatization and then the determination—GC-MS with electron impact (El) ionization operated in the selected ion monitoring (SIM)—are performed. ... 

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