Fragment based lead discovery

Hartshorn MJ, Murray CW, Cleasby A, Frederickson M, Tickle IJ, Jhoti H. Fragment based lead discovery using x-ray crystallography, J Med Chem 2005 48 403-13. 

C. W., Carr, R. Fragment-based lead discovery. Nat. Rev. Drug Discov. 2004,... 

Congreve, M., Carr, R., Murray, C., Jhoti, H. A rule of three for fragment-based lead discovery Drug Discov. Today 2003, 8, 876-877. 

J. M. Blaney, V. Nienaber and S. K. Burley, Fragment-based lead discovery and optimization using X-ray crystallography, computational chemistry, and high throughput organic synthesis, in... 

FBDD reviews (a) Congreve, M. Chessari, G. Tisi, D. Woodhead, A. J. Recent developments in fragment-based drug discovery. J. Med. Chem. 2008, 51, 3661-3680. (b) Erlanson, D. A. Fragment-based lead discovery A chemical update. Curr. Opin. Biotechnol. 2006,17, 643-652. 

Rees, D.C., Congreve, M., Murray, C.W and Carr, R. (2004) Fragment-based lead discovery. Nature Reviews. Drug Discovery, 3, 660-672. 

Design of Screening Collections for Successful Fragment-Based Lead Discovery... 

Key words Fragment-based lead discovery, screening collection, library design, computational filtering, NMR screening... 

Hartshorn, M. J., Murray, C. W., Cleasby, A., Frederickson, M., Tickle, I. J., and Jhoti, H. (2005). Fragment-based lead discovery using X-ray crystallography. Journal of Medicinal Chemistry 48, 403—413. 

M. Congreve, R. Carr, C. Murray and H. Jhoti A Rule of Three for fragment-based lead discovery, Drug Discov. Today, 8, 876-877 (2003). 

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