Biodegradable temporizing dermal matrix

Development history of NovoSorb biodegradable temporizing dermal matrix for major burn injury... 

Proof of concept of cultured composite skin on biodegradable temporizing dermal matrix... 

Long-term implantation of biodegradable temporizing dermal matrix with delayed split-skin grafting... 

The first use of biodegradable temporizing dermal matrix in moderate to severe burn repair... 

Dermal TE using PU scaffolds/membranes requires the precise reconstitution of the skin bilayer. In an ovine full thickness wound model, which tested a PU (biodegradable temporizing matrix BTM-2) [94], the Integra dermal regeneration template was compared to BTM-2. It was found that by 29 days all wound sites had healed comparably [94]. 

The biodegradable polyurethane has been demonstrated to be a capable and versatile material for the production of skin products for major bum victims. As a synthetic, sealed bilayer dermal temporizing matrix, it is already in regular human use in surgical wounds and is the subject of a five patient pilot human bum trial. As the scaffold for CCS production, the foam is nontoxic to cells, allows attachment, collagen deposition and keratinocyte take in vitro, and attachment and take over both in BTM and in fresh wounds in vivo. 

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