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Depressants barbiturates

Kamiya Y, Andoh T, Furuya R, et al Comparison of the effects of convulsant and depressant barbiturate stereoisomers on AMPA-type glutamate receptors. Anesthesiology 90 1704-1713, 1999... [Pg.155]

Children In some people, especially children, barbiturates repeatedly produce excitement rather than depression. Barbiturates may produce irritability, excitability, inappropriate tearfulness, and aggression in children. Safety and efficacy of amobarbital (children younger than 6 years of age) and aprobarbital have not been established. [Pg.1202]

The administration of angiotensin II to an animal with intact baroreceptor reflexes results in reflex bradycardia in response to the marked vasoconstriction. When baroreceptor reflexes are depressed (barbiturate anesthesia) or if vagal tone is inhibited (atropine or vagotomy), angiotensin directly induces cardiac acceleration. [Pg.209]

Respiratory depression Barbiturates suppress the hypoxic and chemoreceptor response to CO2, and overdosage is followed by respiratory depression and death. [Pg.105]

A barbiturate, such as phenobarbital, is a depressant. Barbiturates bind to a receptor for GABA. This keeps channels for chloride ion, CP", transmission open. [Pg.562]

Diffutin (see above) has pronounced adaptogenic (anti-stress and anti-anxiety) activity, as well as being a mild CNS depressant (barbiturate potentiation). It also has a marked inotropic effect in perfused frog heart, and shows no arrhythmogenic properties. In addition, it potentiates the contractile response of guinea pig vas deferens to catecholamines, without inhibition of the uptake of adrenalin. At 500 mg/kg, diffutin is nontoxic to dogs. The use of Canscora in Indian medicine as a herbal remedy for certain mental disorders is supported by these observations. [Pg.226]

Depressant Barbiturates (both short- and long-acting) Ethanol... [Pg.893]

Clayton (1976) reviewed 35 studies that examined the effects of different depressants (barbiturates, non-barbiturates, tranquilizers, and antidepressants) on various skills. After grouping the effects into sensory/perceptual, cognitive, and motor fimctions, it appeared that most drugs did not produce significant impairments on most of the tasks. However, some effects were discemable. Of the sensory/perceptual fimctions, critical flicker fusion and dynamic visual acuity were impaired by several of the drugs whereas static acuity, depth... [Pg.490]

Classes of drugs include hallucinogens (mostly derivatives of phenethylamine or trypt-amine), narcotics (morphine and derivatives), stimulants (cocaine, amphetamines), and depressants (barbiturates, benzodiazepines). [Pg.1215]

Methohexital [18652-93-2] (Brevital), C 4H gN202, (2) is a barbiturate iv anesthetic iaduction agent that has a slightly faster onset than thiopentone and less accumulation. The recovery from anesthesia is also slightly faster and better. However, iaduction is associated with an iacreased iacidence of excitatory phenomena. Methohexital also causes respiratory and cardiovascular depression and is unstable ia solution, necessitating reconstitution before use (99). [Pg.410]

Benzodiazepiaes have largely replaced barbiturates and barbiturate-like agents for use as anxiolytics and sedative—hypnotics. Because benzodiazepiaes rarely produce levels of CNS depression that require therapeutic iatervention, the need for analeptics has decreased considerably. [Pg.463]

A thiazole derivative that incorporates a fragment of the amphetamine molecule shows some CNS stimulant activity more specifically, the compound antagonizes the depression caused by overdoses of barbiturates and narcotics. Reaction of benzalde-hyde with sodium cyanide and benzenesulfonyl chloride gives the toluenesulfony1 ester of the cyanohydrin (141). Reaction of this with thiourea leads directly to aminophenazole (143) It is probable the reaction proceeds by displacement of the tosylate by the thiourea sulfur to give 142 addition of the amino group to the nitrile followed by tautomerization affords the observed product. ... [Pg.248]

All barbiturates have essentially die same mode of action. Depending on the dose given, tiiese drags are capable of producing central nervous system (CNS) depression and mood alteration ranging from mild excitation to mild sedation, hypnosis (sleep), and deep coma These drugs also are respiratory depressants the degree of depression... [Pg.237]

Miscellaneous or nonbarbiturate sedatives and hypnotics have essentially the same mode of action as the barbiturates, that is, they depress the CNS. However,... [Pg.238]

Because narcoticanalgesicsdepressthe CNS(see Chap. 19), the nurse should not administer a barbiturate or miscellaneous sedativesand hypnoticsapproximately 2 hoursbefore or after administration of a narcoticanalgesic or other CNS depressant. If the time interval between administration of a narcotic analgesic and a sedative or hypnotic is less than 2 hours the patient may experien ce severe respiratory depres-son, bradycardia, and unresponsiveness. [Pg.241]

MONITORING AND MANAGING RESPIRATORY DEPRESSION These drugs depress the CNS and can cause respiratory depression. The nurse carefully assesses respiratory function (rate, depth, and quality) before administering a sedative, Vs, to 1 hour after administering the drug, and frequently thereafter. Toxic reaction of the barbiturates can cause severe respiratory depression, hypoventilation, and circulatory collapse. [Pg.243]

The onset of symptoms of barbiturate toxicity may not occur until several hours after the drug is administered. Symptoms of acute toxicity include CNSand respiratory depression, constriction or paralytic dilation of the pupils tachycardia, hypotension, lowered body temperature, oliguria, circulatory collapse, and coma. The nurse should report any symptoms of toxicity to the primary health care provider immediately. [Pg.243]

The barbiturates are contraindicated in patients with known hypersensitivity to the drugs. The barbiturates are used cautiously in patients with liver or kidney disease and those with neurological disorders. The barbiturates (eg, phenobarbital) are used with caution in patients with pulmonary disease and in hyperactive children. When barbiturates are used with other CNS depressants (eg, alcohol, narcotic analgesics, and antidepressants), an additive CNS depressant effect may occur. See Chapter 26 for additional information on the barbiturates. [Pg.257]

The barbiturates may produce marked excitement, depression, and confusion in the elderly. In some individualsthe barbiturates produce excitement rather than depression. The nurse should monitor the older adult carefully during therapy with the barbiturates and report any unusual effects to the primary health care provider. [Pg.260]


See other pages where Depressants barbiturates is mentioned: [Pg.339]    [Pg.32]    [Pg.139]    [Pg.216]    [Pg.718]    [Pg.231]    [Pg.245]    [Pg.114]    [Pg.133]    [Pg.154]    [Pg.465]    [Pg.339]    [Pg.32]    [Pg.139]    [Pg.216]    [Pg.718]    [Pg.231]    [Pg.245]    [Pg.114]    [Pg.133]    [Pg.154]    [Pg.465]    [Pg.51]    [Pg.531]    [Pg.531]    [Pg.534]    [Pg.536]    [Pg.255]    [Pg.409]    [Pg.218]    [Pg.228]    [Pg.237]    [Pg.461]    [Pg.150]    [Pg.261]    [Pg.307]    [Pg.363]    [Pg.7]    [Pg.535]    [Pg.172]    [Pg.254]   
See also in sourсe #XX -- [ Pg.69 , Pg.70 ]




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