Department of Health and Human Services DHHS

Fifth yinnualKeport on Carcinogens Summary 1989, NTP 89-239, U.S. Department of Health and Human Services (DHHS), National Toxicology Program (NTP) of the National Institute of Environmental Health Sciences, Research Triangle Park, N.C., 1989, pp. 24—30. 

Two major panels of experts publish guidelines for the treatment of HIV-infected individuals. Although the recommendations are quite similar, slight differences do exist between the Department of Health and Human Services (DHHS) Guidelines2 and the International AIDS Society-USA (IAS-USA) Panel Recommendations.4 The DHHS Guidelines are updated every 6 months and current and archived versions are available online at www.aidsinfo.nih.gov. The IAS-USA Guidelines were last updated in 2006, and in 2004 prior to that revision. Due to the intense research and constant modifications to therapeutic approaches in the treatment of HIV, the majority of the treatment algorithms and recommendations presented herein follow the most up-to-date information found in the DHHS recommendations. 

The Department of Health and Human Services (DHHS), the International Agency for Research on Cancer (IARC), and EPA have not classified mineral oil hydraulic fluids, polyalphaolefin hydraulic fluids, and organophosphate ester hydraulic fluids for carcinogenic effects. 

The FDA of the U.S. Department of Health and Human Services (DHHS) administers the regulatory controls for the Food, Drug, and Cosmetic Act of 1906 and the 1976 and 1990 amendments, which provide approval for commercial distribution of safe and effective medical devices. The 1976 amendments directed the FDA to regulate medical devices under control levels that are necessary to ensure safety and effectiveness. In order to achieve this task, the Medical Device Law under the amendments required the FDA to issue regulations placing all medical devices on the market at that time into one of three regulatory classes ... 

We have no proof that lead causes cancer in humans. Kidney tumors have developed in rats and mice given large doses of lead. The animal studies have been criticized because of the very high doses used, among other things. The results of high-dose studies should not be used to predict whether lead may cause cancer in humans. The Department of Health and Human Services (DHHS) has determined that lead acetate and lead phosphate may reasonably be expected to be... 

The International Agency for Research on Cancer (IARC 1987) concluded that the evidence for carcinogenicity of lead and inorganic lead compounds was inadequate in humans and sufficient in animals. IARC (1987) classified lead and inorganic lead compounds in IARC Group 2B, possible human carcinogen. The Department of Health and Human Services (DHHS) has determined that lead acetate and phosphate may reasonably be anticipated to be carcinogens based on sufficient evidence from animal studies, but inadequate evidence from human studies (NTP 1994). 

The weight of evidence suggests that PbB levels of "10-15 g/dL and possibly lower" are the levels of concern (ATSDR 1993 Davis 1990 EPA 1986). The Department of Health and Human Services (DHHS) has determined that primary prevention activities should begin at blood lead levels of 10 g/dL in children (CDC 1991). 

From Department of Health and Human Services (DHHS) Panel on Antiretroviral Guidelines for Adults and Adolescents. Guidelines for the use of antiretroviral agents in HIV-infected adults and adolescents. October 10, 2006, http//AIDSinfo.NIH.gov. 

There is no evidence that exposure to //-hexane increases the risk of cancer in people. No reliable information is available on whether //-hexane causes cancer in animals. In an animal experiment with commercial hexane (which contains //-hexane), an increase in liver cancer was found in female mice after exposure for 2 years. No increase was found in male mice or in rats of either sex. Commercial hexane is a mixture, and we do not know what parts of the mixture caused the cancer in the female mice. //-Hexane has not been characterized for carcinogenicity by the Department of Health and Human Services (DHHS), the International Agency for Research on Cancer (IARC), or the Environmental Protection Agency (EPA). 

National Institute for Occupational Safety and Health. (1984). Registry of Toxic Effects of Chemical Substances, 11th ed., Vols. 1-3. Department of Health and Human Services DHHS No. 83-107, 1983 and RTECS Supplement DHHS 84-101, Washington, D.C. 

IA R C, U.S. EPA, AND U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES (DHHS) CLASSIFICATIONS FOR CARCINOGENICITY OF CHEMICAL AGENTS... 

Department of Health and Human Services (DHHS), Office of the Inspector General. 2000a. Medicare program, prospective payment system for hospital outpatient services. Fed Reg 65 18433 available at www.gpoaccess. gov/fr/. 

Department of Health and Human Services (DHHS). 2000b. Program Memorandum Intermediaries/ Carriers, Transmittal AB-00-67 July 20, 2000. Available at www.cms.hhs.gov/transmittals/downloads/ ab0067.pdf. 

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