Myeloid dendritic cells

Lanzavecchia A Specialization and complementar- 57 ity in microbial molecule recognition by human myeloid and plasmacytoid dendritic cells. Eur J Immunol 2001 31 3388-3393. 

Dendritic cells (DCs) are functionally classified into myeloid (MDCs) and plasma-cytoid DCs (PDCs), both of which are potent professional antigen presenting cells (APC) but vary in the expression of a number of surface molecules. They also exhibit differences in their susceptibility to various strains of HIV-1 (Lore et al. 2005 Smed-Sorensen et al. 2005). Their role in the dissemination of HIV-1 is of... 

Lore K, Smed-Sorensen A, Vasudevan J, Mascola JR, Koup RA (2005) Myeloid and plasmacytoid dendritic cells transfer HIV-1 preferentially to antigen-specific CD4-t T cells. J Exp Med... 

Fig. 2. Chemokine receptors on DC subtypes. mDCpre, myeloid dendritic cell precursor pDCpre, plasmacytoid dendritic cell precursor.

Langenkamp A, Nagata K, Murphy K, Wu L, Lanzavecchia A, Sallusto F. Kinetics and expression patterns of chemokine receptors in human CD4+ T lymphocytes primed by myeloid or plasmacytoid dendritic cells. Eur J Immunol 2003 33 474 182. 

Miyahara N, Yang ES, Taube C, Joetham A, Park JW, Dakhama A, Gelfand EW Importance of myeloid dendritic cells in persistent airway disease after repeated allergen exposure. Am J Respir Grit Care Med 2006 173 42-55. 

Upham JW, Denburg JA, O Byrne PM Rapid response of circulating myeloid dendritic cells to inhaled allergen in asthmatic subjects. Clin Exp Allergy 2002 32 818-823. 

Peripheral blood mononuclear cells (PBMCs) that include mainly monocytes, T-cells, and B-cells, and smaller portions of NK cells and dendritic cells of myeloid and plasmacytoid origin, are a critical component of immune system. PBMC-based models are widely used in research of cell-mediated immunity and for screening of compounds for immunomodulatory effects. 

Penna G et al Vitamin D receptor agonists in the treatment of autoimmune diseases Selective targeting of myeloid but not plasmacytoid dendritic cells. J Bone Min Res 2007 22(Suppl 2) 69. 

Lymphoid dendritic cells promote negative selection in the thymus. This may be attributed to their ability to induce fas-mediated apoptosis. Based on their ability to cause apoptosis and their ability to eliminate self-reactive T cells, lymphoid dendritic cells exhibit a regulatory function instead of a stimulatory immune effector function. Myeloid dendritic cells also have differential effects. For example, T cells can be primed to selectively activate THi responses by CD14-derived myeloid dendritic cells. Naive B cells can be activated in the presence of CD40L and IL-2 to secrete IgM by CD34+, CD14-derived myeloid dendritic cells. This effect on naive B cells is not observed with CD la-derived dendritic cells. 

Schematic representation of the hematopoietic cascade in mice and human (hum). All the cells of the hematopoietic system are positive for antigen CD45. Based on this, the dynamics of surface antigen expression along development of different mature cells derived from the hematopoietic stem cell system can be observed. Rounded arrows indicate self-renewal potential. Smooth thinner arrows indicate directions of cellular differentiation. The identification of CDs (clusters definition) and other antigen cell markers are listed in the glossary. (LT-HSC - long term hematopoietic stem cell ST-HSC - short term hematopoietic stem cell MPP - multipotent progenitor CLP - common lymphoid precursor CMP - common myeloid precursor GMP - granulocyte-monocyte precursor MEP - megacaryocyte-erythrocyte precursor T - T lymphocyte B - B lymphocyte NK - natural killer cell DC - dendritic cell).

Recombinant human granulocyte macrophage colony-stimulating factor o stimulates the production of neutrophils, monocytes/ macrophages, myeloid-derived dendritic cells... 

MCP-1 is a chemokine, wliich attracts monocytes and myeloid dendritic cells to sites of injuiy or inflaimnation. 

Messmer D, Messmer B, Chiorazzi N. The global transcriptional maturation pro am and stimuli-specific gene expression profiles of human myeloid dendritic cells. Int Immunol 2003 15(4) 491-503. 

Wu L, Vandenabeele S, Georgopoulos K (2001) Derivation of dendritic cells from myeloid and lymphoid precursors. Int Rev Immunol 20 117-135. 

Member of prostaglandin family may have both pro- and anti-apoptotic actions Receptor on phagocytes for IgG bound to an antigen Antigen-presenting surface molecule on immunocompetent cells Inflammatory cytokine released by activated astrocytes and microgha Chemokine diat attracts monocytes and myeloid dendritic cells... 

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