Immune effector functions

Scallon, BJ. et al., Chimericanti- TNF-a monoclonal antibody cA2 binds recombinant transmembrane TNF-a and activates immune effector functions, Cytokine, 7, 251,1995. 

IL-12-stimulated IFN-y production and NK cell activation further potentates the overall immune response, not only to infectious agents but also against transformed cells. Cytotoxic T cells and NK cells represent two of the most important immune effector functions against cancer. IL-12-mediated immunological activity also renders this cytokine a potentially... 

Lymphoid dendritic cells promote negative selection in the thymus. This may be attributed to their ability to induce fas-mediated apoptosis. Based on their ability to cause apoptosis and their ability to eliminate self-reactive T cells, lymphoid dendritic cells exhibit a regulatory function instead of a stimulatory immune effector function. Myeloid dendritic cells also have differential effects. For example, T cells can be primed to selectively activate THi responses by CD14-derived myeloid dendritic cells. Naive B cells can be activated in the presence of CD40L and IL-2 to secrete IgM by CD34+, CD14-derived myeloid dendritic cells. This effect on naive B cells is not observed with CD la-derived dendritic cells. 

Scallon, B. J., Moore, M. A., Trinh, H., Knight, D. M., and Ghrayeb, J. (1995). Chimeric anti-TNFa monoclonal antibody cA2 binds recombinant transmembrane TNFa and activates immune effector functions. Cytokine1 , 251-259. 

In theory, all genes coding for products that are involved in the induction and maintenance of self-tolerance and in regulating immune effector functions as well as organ-specific functions may be involved in defining individual susceptibility. The most clearly established genetic association is with specific alleles within the MHC gene complex. However, with rare exceptions, a specific MHC haplotype is not sufficient for development of autoimmune disease. 

Rituximab Binds to the CD20 antigen on B-lymphocytes and recruits immune effector functions to mediate lysis. Used in B cell non-Hodgkin s lymphoma... 

Scallon BJ, Moore MA, Trinh H, et al. Chimeric anti-TNF-alpha monoclonal antibody cA2 hinds recombinant transmemhrane TNF-alpha and activates immune effector functions. Cytokine 1995 7 251-259. 

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