Dendrites development

Alfano DP, Petit TL. 1982. Neonatal lead exposure alters the dendritic development of hippocampal dentate granule cells. Exp Neurol 75 275-288. 

These studies offer a new model of concomitant behavioral, chemical, and morphological abnormalities associated with a defined Insult at a critical period 1n dendritic development. This model may have some special Importance 1n relation to minimal brain dysfunctions, particularly since no blood-brain barrier protects the fetal brain from antibodies 1n the maternal circulation. 

We should note finally that dysbindin-1 may affect cognition indirectly via effects on neuronal development, especially axonal and dendritic development (see Section 2.2.6.5A). Even in adulthood, however, it is possible that the protein affects dendritic spine growth associated with long-term potentiation via its affect on NMDAR (Andrews et al., 2007 see Sections 2.2.6A.2.8 and 2.2.6.5J). 

Lee A, Li W, Xu K, Bogert BA, Su K, Gao FB (2003) Control of dendritic development by the Drosophila fragile X-related gene involves the small GTPase Racl. Development 130 5543-5552... 

Van Aelst L, Cline HT (2004) Rho GTPases and activity-dependent dendrite development. Curr... 

Stein et al. (1991) reviewed the neuropathological findings observed in human autopsies of people with CH and EC. These findings include normal brain architecture, minimal cerebral atrophy, a reduced number of pyramidal and Betz neurons in each layer V, and abnormal axonal and dendritic development of the pyramidal neurons in the cerebral cortex and brainstem. Retarded myelination (Duckett, 1994) and diminished size of pyramidal tracts may also be observed (Eayrs, 1960). 

Brown, W.J., Verity, M.A., and Smith, R.L., 1976, Inhibition of cerebellar dendrite development in neonatal thyroid deficiency. Neuropath. apol, Neurobiol., 2 191. 

Possible relationship to hippocampal dysfunction. Behav. Neural Biol, 32, 319 Alfano, D. P. and Petit T. L. (1982). Neonatal lead exposure alters the dendritic development of hippocampal dentate granule cells. Exp. Neurol, 75, 275 Anden, N. E., Robenson, A., Fuxe, K. and Hokfelt, T. (1967). Evidence for dopamine receptor stimulation by apomorphine. J. Pharm. Pharmacol, 19, 627 Angell, N. F. and Weiss, B. (1982). Operant behavior of rats exposed to lead before or after weaning. Toxicol Appl Pharmacol, 63, 62 Archer, J. (1973). Tests for emotionality in rats and mice a review. Animal Behav., 21, 205... 

McClain, R. M. and Becker, B. A. (1972). Effects of organolead compounds on rat embryonic and fetal development Toxicol. Appl. Pharmacol., 21, 265 McClain, R. M. and Becker, B. A. (1975). Teratogenicity, fetal toxicity and placental transfer of lead nitrate in rats. Toxicol. Appl. Pharmacol., 31, 72 McConnell, P. and Berry, M. (1978). The effects of undernutrition on Purkinje cell dendritic growth in the rat. J. Comp. Neurol., Yll 159 McConnell, P. and Berry, M. (1979). The effects of postnatal lead exposure on Purkinje cell dendritic development in the rat. Neuropathol. Appl. Neurobiol., 5, 115... 

Ahnert-Hilger, G., Holtje, M., Grosse, G., Pickert, G., Mucke, C., Nixdorf-Bergweiler, B., Boquet, P., Hofmann, F., and Just, I. (2004). Differential effects of Rho GTPases on axonal and dendritic development in hippocampal neurones. J. Neurochem. 90, 9-18. Albertinazzi, C, Za, L., Paris, S., and De Curtis, I. (2003). ADP-ribosylation factor 6 and a functional PIX/p95-APPl complex are required for RaclB-mediated neurite outgrowth. Mol. Biol. Cell 14, 1295-1307. 

Whitford, K. L., Marillat, V., Stein, E., Goodman, C. S., Tessier-Lavigne, M., Chedotal, A., and Ghosh, A. (2002). Regulation of cortical dendrite development by Slit-Robo interactions. Neuron 33, 47-61. 

Patrick G. W. Anderson W. J. and Brophy P. D. (1979). Purkinje cell dendritic development in lead treated cats and rats. Soc. Neurosci. Abst. No. 562. 

As with the vascular pathology, the most pronounced neuronal and glial effects of lead poisoning ai e seen in the cerebellum. Cerebellar weight and total cell number ai e reduced" and the size and morphology of Purkinje cell bodies cire abnormal."" " The intemeuron circuitry of the cerebellum is also altered, since the dendritic development of the Purkinje cells, which form the only efferent elements of the cerebellar cortex, is markedly disturbed by lead exposure. Press observed a decrease in the rate of Purkinje cell maturation in lead-poisoned rat pups from about 5 d onwards such that, at 10 d, the leaded cells retained more perisomatic processes than controls and the den-... 

McConnell, P. and Beriy, M. (1979) The effects of postnatal lead exposure on Purkinje cell dendritic development in the rat. Neuropath. Appl. Neurobiol. 5, 115-132. 

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