Dendrimers delivery systems

Florence, A.T., N. Hussain, Transcytosis of nanoparticle and dendrimer delivery systems evolving vistas. Adv Drug Deliv Rev 2001, 50 (Suppl 1), S69-S89. 

In macromolecular dmg delivery systems, dmgs are attached to polymeric compounds, such as synthetic polymers [60], dendrimers [61], and antibodies [62], in order to enhance the delivery of the active substance to the diseased tissue and to reduce the toxicity to healthy tissue. The use of macromolecular delivery systems provides several advantages extension of the half-life of the dmg, the ability to introduce targeting moieties into the carrier, the possibility of triggered dmg release, and the aforementioned reduced cytotoxicity. 

Pan B, Cui D, Sheng Y, Ozkan CS, Gao F, et al. (2007). Dendrimer-modified magnetic nanoparticles enhance efficiency of gene delivery system. Cancer Res. 67 8156-8163. 

An important application of polymers in medicine is in advanced drug-delivery systems. These materials control the drug concentration and delivery rate in the body. Hyperbranched polyesters have been suggested for such systems [111]. However, most applications within this field, described in the literature, deal with dendrimers and not with hyperbranched polymers. 

Kono K. Apphcation of dendrimers to dmg delivery systems—from the view point of carrier design based on nanotechnology. Dmg Deliv Syst 2002 17 462-470. 

The application of dendritic polymers as drug delivery systems has gained interest mainly due to their inertness relative to temperature, solvent, and pH extremes [38]. However, dendritic polymers require further improvements in biocompability and biodistribution profiles. The cytotoxicity of dendrimers currently has been primarily studied in vitro. 

Novel dendrimers have novel and unique properties that make them promising candidates for use in the development of nanoscale devices and in drug delivery systems. 

Owing to the scope offered by their architecture for modification and functionalisation, dendrimers have been considered for therapeutic applications and as delivery systems for active ingredients, although precisely the plethora of possible variation and optimisation measures places demands on time and effort. 

Some scientists have suggested, for example, that dendrimers could constitute the basis of a very highly specific drug delivery system. The drug needed by a patient would first he inserted into... 

Some researchers see a bright future for dendrimers in many different industrial, medical, research, and consumer applications. One company that produces dendrimers lists applications in drug delivery systems, gene transfection, biotechnology, sensors for diagnostics and detection systems, carbon fiber coatings, microcontact printing, adhesion, molecular batteries, catalysis, separation systems, lasers, composites, and ultrathin films used in optics. 

Barth et alJ30 have reported the preparation of boronated starburst dendrimer— monoclonal antibodies immunoconjugates as a potential delivery system for boron neutron capture therapy. 31 32 Starburst dendrimers have also been employed as linker molecules for the covalent connection of synthetic porphyrins to antibodies J33 ... 

Boronated starburst dendrimer-monoclonal antibody immunoconjugates Evaluation as a potential delivery system for neutron capture therapy. [R. F. Barth, D. M. Adams, A. H. Soloway, F. Alam, M. V. Darby, Bioconj. Chem. 1994, 5(1), 58-66] [ 364]. 

Dendrimers have been successfully used as a delivery system for antisense oligonucleotides (ODNs). ° "" Hughes et al. " reported the significant enhancement of the effectiveness of antisense ODNs in the presence of non-toxic concentrations of G5 PAMAM dendrimer. Bielinska et al. " reported the enhanced activity of antisense ODNs and antisense cDNA plasmids in the presence of PAMAM dendrimers in an in vitro cell culture system. Dendrimer was believed to enhance the transfer of ODN into cells. The electrostatic binding of the phosphodiester ODNs to dendrimers also extended their intracellular survival. Dendrimers at concentrations required to be effective ODN carriers were reported to be non-cytotoxic. 

Wiwattanapatapee, R. Jee, R.D. Duncan, R. PAMAM dendrimers as a potential oral drug delivery system dendrimer complexes with piroxicam. Proc. Int. Symp. Control. Release Bioact. Mater. 1999, 26, 145-146. 

Twyman, L.J. Beezer, A.E. Esfand, R. Hardy, M.J. Mitchell, J.C. The synthesis of water soluble dendrimers, and their application as possible drug delivery systems. Tetrahedron Lett. 1999, 40, 1743-1746. 

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