Monoclonal antibodies immunoconjugate

Barth, R.F., Adams, D.M., Soloway, A.H., Alam, F., and Darby, M.V. (1994) Boronated starburst den-drimer-monoclonal antibody immunoconjugates Evaluation as a potential delivery system for neutron capture therapy. Bioconjugate Chem. 5, 58-66. 

Salmon, S.E. (1989) Monoclonal antibody immunoconjugates for cancer. Antibody, Immunoconjugates, Radiopharm. 2, 63-70. 

Barth et alJ30 have reported the preparation of boronated starburst dendrimer— monoclonal antibodies immunoconjugates as a potential delivery system for boron neutron capture therapy. 31 32 Starburst dendrimers have also been employed as linker molecules for the covalent connection of synthetic porphyrins to antibodies J33 ... 

Tyie, P., and Ram, B.P., Monoclonal Antibodies, Immunoconjugates, and Liposomes as Targeted Therapeutic Systems, Targeted Therapeutic Systems, P. iyie and B.P. Ram (eds.)(New York, NY Marcel Dekker, 1990),... 

T.J. McKearn, A.D. Lopes, R.D. Radcliffe, D.J. Coughlin, R.T. Hrubiec and J.D. Rodwell, Abstracts of Papers, Third Int. Conf. on Monoclonal Antibody Immunoconjugates for Cancer, San Diego, February 4-6, 1988,... 

Foglesong, P.D., Winkler, M.A., Price, J.O., Marshall, G.D., Reagh, S.H., Bush, D.A., Hixson, K.S., and West, W.H. (1989) Preparation and analysis of bifunctional immunoconjugates containing monoclonal antibodies OKT3 and BABR1. Cancer Immunol. Immunother. 30(3), 177-184. 

Noguchi, A., Takahashi, T., Yamaguchi, T., Kitamura, K., Takakura, Y., Hashida, M., and Sezaki, H. (1992) Preparation and properties of the immunoconjugate composed of anti-human colon cancer monoclonal antibody and mitomycin C—Dextran conjugate. Bioconjugate Chem. 3, 132-137. 

Reisfeld, R.A., Yang, H.M., Mullet B., Wargalla, U.C., Schrappe, M., and Wrasidlo, W. (1989) Promises, problems, and prospects of monoclonal antibody-drug conjugates for cancer therapy. Antibody, Immunoconjugates, Radiopharm. 2, 217-224. 

Lind P, Lechner P, Hausmann B. 1991. Development of human anti-mouse antibodies (HAMA) after single and repeated diagnostic application of intact murine monoclonal antibodies. Antibody Immunoconjug Radiopharm. 4 811-818. 

Delivery of boron-10 for neutron capture therapy by means of monoclonal antibody-starburst dendrimer immunoconjugates. [R. F. Barth, A. H. Soloway, D. M. Adams, F. Alam, In Prog. Neutron Capture Ther. Cancer, (Eds. B. J. Allen, D. E. Moore, B. V. Harrington, Plenum, New York, 1992] [ 1871],... 

Immunoconjugate murine anti-CD20 monoclonal antibody + Y90 + In111 reacts with normal and malignant B lymphocytes... 

Various monoclonal antibodies have been developed to be used as carrier molecules or as immunoconjugates to target drugs, enzymes, isotopes, or toxins to tumor cells. Some of the available data have been summarized (11), but there is still insufficient evidence of chnical benefit. 

Ogden JR, Leung K, Runda SA, Telander MW, Avner BP, Liao SK, Thurman GB, Oldham RK (1989) Immunoconjugates of doxorubicin and murine antihuman breast carcinoma monoclonal antibodies prepared via an N-hydroxysuccinimide active ester intermediate of cis-aconityl-doxorubicin preparation and in vitro cytotoxicity. Mol Biother 1 170-174... 

Hudecz F, Ross H, Price MR, et al. Immunoconjugate design a predictive approach for coupling of daunomycin to monoclonal antibodies. Bioconjug Chem 1990 1 197-204. 

Ngai WM, Reilly RM, Polihronis J, Shpitz B. In-vitro and in-vivo evaluation of streptavidin immunoconjugates of the second-generation TAG-72 monoclonal antibody CC49. Nucl Med Biol 1994 22 77-86. 

Lloyed, K.O., Human tumour antigens. Targets for mouse monoclonal antibodies. In Immunoconjugates. C.W. Vogel (Ed.), Oxford University Press, New York, Oxford, 1987. 

Reilly R M, Marks A, Law J, et al. (1992). In-vitro stability of EDTA and DTPA immunoconjugates of monoclonal antibody 2G3 labelled with In-111. Appl. Radial, hot. 43 961-967. 

BR96 - Doxorubicin immunoconjugate SON 15. BMS 182248. BR96 - DOX Chimeric human/mouse monoclonal antibody linked to 8 doxorubicin mols. Antibody directed against Lewis-Y antigen. 

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