Delta aminolevulinic acid

Narayan S, Misra UK. 1985. Delta-aminolevulinic acid synthetase and heme oxygenase activity in lung and liver of rats given DDT and endosulfan intratracheally. Bull Environ Contam Toxicol 34 24-28. [Pg.307]

Various minor hematological effects have been noted in animals. Rats exposed to 50-800 ppm of trichloroethylene continuously for 48 or 240 hours showed time- and dose-related depression of delta-aminolevulinate dehydratase activity in liver, bone marrow, and erythrocytes (Fujita et al. 1984 Koizumi et al. 1984). Related effects included increased delta-aminolevulinic acid (ALA) synthetase activity, reduced heme saturation of tryptophan pyrrolase and reduced cytochrome P-450 levels in the liver and increased urinary excretion of... [Pg.41]

Koizumi A, Fujita H, Sadamoto T, et al. 1984. Inhibition of delta-aminolevulinic acid dehydratase by trichloroethylene. Toxicology 30 93-102. [Pg.274]

Alterations in blood heme metabolism have been proposed as a possible indicator of the biological effects of hydrogen sulfide (Jappinen and Tenhunen 1990), but this does not relate to the mechanism of toxicity in humans. The activities of the enzymes of heme synthesis, i.e., delta-aminolevulinic acid synthase (ALA-S) and heme synthase (Haem-S), were examined in 21 cases of acute hydrogen sulfide toxicity in Finnish pulp mill and oil refinery workers. Subjects were exposed to hydrogen sulfide for periods ranging from approximately 1 minute to up to 3.5 hours. Hydrogen sulfide concentrations were considered to be in the range of 20-200 ppm. Several subjects lost consciousness for up to 3 minutes. [Pg.114]

ALAD = delta-aminolevulinic acid dehydratase DMSA= dimercaptosuccinic acid NMDA= N-methyl- D-aspartate PCBs = polychlorinated biphenyls XRF = X-ray fluorescence... [Pg.370]

Astrin KH, Bishop DF, Wetmur JG, et al. 1987. Delta-aminolevulinic acid dehydratase isozymes and lead toxicity. Ann NY Acad Sci 514 23-29. [Pg.489]

Benkmann H-G, Bogdanski P, Goedde HW. 1983. Polymorphism of delta-aminolevulinic acid dehydratase in various populations. Hum Hered 33 62-64. [Pg.493]

Davis JR, Avram MJ. 1978. A comparison of the stimulatory effects of cadmium and zinc on normal and lead-inhibited human erythrocytic delta-aminolevulinic acid dehydratase activity in vitro. Toxicol Appl Pharmacol 44 181 -190. [Pg.507]

Goering PL, BA. 1984. Regulation of lead inhibition of delta-aminolevulinic acid dehydratase by a high affinity renal lead-binding protein. J Pharmacol Exp Ther 231 66-71. [Pg.526]

Goering PL, BA. 1987. Metal constitution of metallothionein influences inhibition of delta-aminolevulinic acid dehydratase (porphobiligen synthase) by lead. Biochem J 245 339-345. [Pg.526]

Hayashi M. 1983. Lead toxicity in the pregnant rat 11. Effects of low-level lead on delta-aminolevulinic acid dehydratase activity in maternal and fetal blood or tissue. Ind Health 21 127-135. [Pg.531]

Herber RFM. 1980. Estimation of blood lead values from blood porphyrin and urinary delta-aminolevulinic acid levels in workers. Int Arch Occup Environ Health 45 169-179. [Pg.532]

Hemberg S, Nikkanen J, Mellin G, et al. 1970. delta-Aminolevulinic acid dehydrase as a measure of lead exposure. Arch Environ Health 21 140-145. [Pg.532]

Kuhnert PM, Erhard P, Kuhnert BR. 1977. Lead and delta-aminolevulinic acid dehydratase in RBC s of urban mothers and fetuses. Environ Res 14 73-80. [Pg.541]

Lauwerys R, Buchet J-P, Roels HA, et al. 1974. Relationship between urinary delta-aminolevulinic acid excretion and the inhibition of red cell delta-aminolevulinate dehydratase by lead. Clin Toxicol 7 383-388. [Pg.543]

Meredith PA, Moore MR, Campbell BC, et al. 1978. Delta-aminolevulinic acid metabolism in normal and lead-exposed humans. Toxicology 9 1-9. [Pg.549]

Millar JA, Cummings RLC, Battistini V, et al. 1970. Lead and delta-aminolevulinic acid dehydratase levels in mentally retarded children and in lead-poisoning in suckling rats. Lancet 2 695-698. [Pg.550]

Nieburg PI, Weiner LS, Oski BF, et al. 1974. Red blood cell delta-aminolevulinic acid dehydrase activity. Am J Dis Child 127 348-350. [Pg.555]

Oishi H, Nomiyama H, Nomiyama K, et al. 1996. Fluorometric HPLC determination of delta-aminolevulinic acid (ALA) in the plasma and urine of lead workers biological indicators of lead exposure. J Anal Toxicol 20(2) 106-10. [Pg.560]

Robinson TR. 1974. Delta-aminolevulinic acid and lead in urine of lead antiknock workers. Arch Environ Health 28 133-138. [Pg.568]

Roels HA, Balis-Jacques MN, Buchet J-P, et al. 1979. The influence of sex and of chelation therapy on erythrocyte protoporphyrin and urinary delta-aminolevulinic acid in lead-exposed workers. J Occup Med 21 527-539. [Pg.568]

Sakai T, Morita Y. 1996. Delta-aminolevulinic acid in plasma or whole blood as a sensitive indicator of lead effects, and its relation to the other heme-related parameters. Int Arch Occup Environ Health 68(2) 126-132. [Pg.571]

Schwartz BS, Lee BK, Stewart W, et al. 1997. Delta-aminolevulinic acid dehydratase genotype modifies four hour urinary lead excretion after oral administration of dimercaptosuccinic acid. Occup Environ Med 54(4) 241-246. [Pg.573]

Smith CM, Wang X, Hu H, et al. 1995. A polymorphism in the delta-aminolevulinic acid dehydratase gene may modify the pharmacokinetics and toxicity of lead. Environ Health Perspect 103 248-253. [Pg.576]

Tabuchi T, Okayama A, Ogawa Y, et al. 1989. A new HPLC fluorimetric method to monitor urinary delta-aminolevulinic acid (ALA-U) levels in workers exposed to lead. Int Arch Occup Environ Health 61 297-302. [Pg.579]

Thomasino JA, Zuroweste E, Brooks SM, et al. 1977. Lead, zinc and erythrocyte delta-aminolevulinic acid dehydratase Relationships in lead toxicity. Arch Environ Health 32 244-247. [Pg.580]

Tomokuni K, IchibaM. 1988. A simple method for colorimetric determination of urinary delta-aminolevulinic acid in workers exposed to lead. Jpn J Ind Health 30 52-53. [Pg.580]

Tomokuni K, Ichiba M, Hirai Y. 1988. Species difference of urinary excretion of delta-aminolevulinic acid and coproporphyrin in mice and rats exposed in lead. Toxicol Lett 41 255-259. [Pg.580]

Haeger-Aronsen B, Schutz A, Abdulla M. 1976. Antagonistic effect in vivo of zinc on inhibition of delta-aminolevulinic acid dehydratase by lead. Arch Environ Health July/Aug 215-220. [Pg.623]

Doring, F., et al. Delta-aminolevulinic acid transport by intestinal and renal peptide transporters and its physiological and clinical implications. J. Clin. Invest. 1998, 101, 2761-2767. [Pg.272]

Castrale, J.S. and M. Oster. 1993. Lead and delta-aminolevulinic acid dehydratase in the blood of mourning doves dosed with lead shot. Proc. Indiana Acad. Sci. 102 265-272. [Pg.327]

Conner, E.A. and B.A. Fowler. 1994. Biochemical and immunological properties of hepatic delta-aminolevulinic acid dehydratase in channel catfish (Ictalurus punctatus). Aquat. Toxicol. 28 37-52. [Pg.327]

Dieter, M.P. 1979. Blood delta-aminolevulinic acid dehydratase (ALAD) to monitor lead contamination in canvasback ducks (Aythya valisineria). Pages 177-191 in National Academy of Sciences. Animals as Monitors of Environmental Pollutants. Washington, D.C. [Pg.328]

Dieter, M.P. and M.T. Finley. 1979. Delta aminolevulinic acid dehydratase enzyme activity in blood, brain, and liver of lead-dosed ducks. Environ. Res. 19 127-135. [Pg.329]

Johansson-Sjobeck, M.J. and A. Larsson. 1979. Effects of inorganic lead on delta-aminolevulinic acid dehydratase activity and hematological variables in the rainbow trout, Salmo gairdnerii. Arch. Environ. Contam. Toxicol. 8 419-431. [Pg.334]

Scheuhammer, A.M. 1987a. Erythrocyte delta-aminolevulinic acid dehydratase in birds. I. The effects of lead and other metals in vitro. Toxicology 45 155-163. [Pg.340]

Scheuhammer, A.M. and L.K. Wilson. 1990. Effects of lead and pesticides on delta-aminolevulinic acid dehydratase of ring doves (Streptopelia risoria). Environ. Toxicol. Chem. 9 1379-1386. [Pg.340]

Schmitt, C.J., M.L. Wildhaber, J.B. Hunn, T. Nash, M.N. Tieger, and B.L. Steadman. 1993. Biomonitoring of lead-contaminated Missouri streams with an assay for erythrocyte delta-aminolevulinic acid dehydratase activity in fish blood. Arch. Environ. Contam. Toxicol. 25 464-475. [Pg.341]

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