3-Aminolevulinate dehydratase

Various minor hematological effects have been noted in animals. Rats exposed to 50-800 ppm of trichloroethylene continuously for 48 or 240 hours showed time- and dose-related depression of delta-aminolevulinate dehydratase activity in liver, bone marrow, and erythrocytes (Fujita et al. 1984 Koizumi et al. 1984). Related effects included increased delta-aminolevulinic acid (ALA) synthetase activity, reduced heme saturation of tryptophan pyrrolase and reduced cytochrome P-450 levels in the liver and increased urinary excretion of... 

Fujita H, Koizumi A, Yamamoto M, et al. 1984. Inhibition of delta-aminolevulinate dehydratase in trichloroethylene-exposed rats, and the effects on heme regulation. Biochem Biophys Acta 800 1-10. 

Lauwerys R, Buchet J-P, Roels HA, et al. 1974. Relationship between urinary delta-aminolevulinic acid excretion and the inhibition of red cell delta-aminolevulinate dehydratase by lead. Clin Toxicol 7 383-388. 

Petrucci R, Leonardi A, Battistizzi G. 1982. The genetic polymorphism of human delta-aminolevulinate dehydratase in Italy. Hum Genet 60 289-290. 

Wetmur JG. 1994. Influence of the common human delta-aminolevulinate dehydratase polymorphism on lead body burden. Environ Health Perspect 102(Suppl 3) 215-219. 

AMINOLEVULINATE DEHYDRATASE 5-AMINOLEVULINATE SYNTHASE AMINOMALONATE DECARBOXYLASE (R)-3-Amino-2-methylpropionate-pyruvate aminotransferase,... 

Tomokuni K, Ogata M. 1980. Comparative study of effects of lead on the activity of erythrocyte pyrimidine 5 -nucleotidase and delta-aminolevulinate dehydratase in vivo and in vitro. Arch Toxicol 45 197-201. 

An example of the influence of extraneous aluminum in an in vivo study with animals can be seen in Fig. 16. The graph shows the results of aluminum determination in brain and liver of mice in a study of the effect of aluminum sulfate on delta-aminolevulinate dehydratase from these organs [110], before and after measures to avoid aluminum contamination had been adopted. In a first attempt to check the way to kill the animals and how to digest the samples, the animals were sacrificed with no measures taken to avoid contamination. The results from this experiment, when compared with those after controlling extraneous aluminum as much as possible, show an aluminum level at least 10 times higher. The results also show that, due to the extent and to the randomness of the distribution of the contamination, there are no significant differences between controls and Al-treated animals, when no attempts to avoid contamination are adopted. 

Contents W. G.Zurrrft The Molecular Basis of Biological Dinitrogen Fixation. -J.J.R. Frausto da Silva, R. J. P. Williams The Uptake of Elements by Biological Systems. - A.M.Cheh, J.B.Neilands The -Aminolevulinate Dehydratases Molecular and Environmental Properties. - P.J.Sadler The Biological Chemistry of Gold. A Metallo-Drug and Heavy-Atom Label with Variable Valency. 

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