Delta Aminolevulinic acid synthetase

Narayan S, Misra UK. 1985. Delta-aminolevulinic acid synthetase and heme oxygenase activity in lung and liver of rats given DDT and endosulfan intratracheally. Bull Environ Contam Toxicol 34 24-28. 

Decrease in weight gain moderate liver pathology gross accumulations of hepatic porphyrins and increased delta-aminolevulinic acid synthetase activity Decrease in weight gain comparatively small increase in liver weight... 

Pretreatment with the Type I substrate, ethylmorphine, resulted in 100% mortality in both rats and mice, and aminopyrine pretreatment resulted in 100% and 64% mortality in rats and mice, respectively, exposed to disulfoton (Pawar and Fawade 1978). Nickel chloride, cobalt chloride, or cycloheximide decreased the levels of cytochrome bs, cytochrome c reductase, and total heme in rats (Fawade and Pawar 1983). These electron transport components were further decreased in rats pretreated with these inhibitors and given a single dose of disulfoton. Data from this study suggests an additive effect, since disulfoton also decreases the activities of these components. Evidence of an additive effect between disulfoton and these metabolic inhibitors was suggested by the decrease in ethylmorphine N-demethylase and acetanilide hydroxylase activities when rats were given an inhibitor followed by disulfoton. In another experiment, these inhibitors decreased the activity of delta-aminolevulinic acid synthetase, but this decrease was reversed when disulfoton was administered. 

Cadmium in the body is known to affect several enzymes. It is believed that the renal damage that results in proteinuria is the result of cadmium adversely affecting enzymes responsible for reabsorption of proteins in kidney tubules. Cadmium also reduces the activity of delta-aminolevulinic acid synthetase (Figure 10.3), arylsulfatase, alcohol dehydrogenase, and lipoamide dehydrogenase, whereas it enhances the activity of delta-aminolevulinic acid dehydratase, pyruvate dehydrogenase, and pyruvate decarboxylase. 

Poland A, Glover E. 1973a. Chlorinated dibenzo-p-dioxins Potent inducers of delta-aminolevulinic acid synthetase and aryl hydrocarbon hydroxylase 2. Study of the structure-activity relationship. Mol Pharmacol 9 736-747. 

R.R. Sinclair, S. Granick (1975). Heme control on the synthesis of delta-aminolevulinic acid synthetase in cultured chick embryo liver cells. Ann. NY Acad. Sci., 244, 509-520. 

Levere, R. D., and Granick, S. (1965). Control of hemoglobin synthe.sis in the cultured chick blastoderm by delta-aminolevulinic acid synthetase increase in the rate of hemoglobin formation with delta-aminolevulinic acid. Proc. Natl. Acad. Sci. U.S. 54, 134-137. 

Various minor hematological effects have been noted in animals. Rats exposed to 50-800 ppm of trichloroethylene continuously for 48 or 240 hours showed time- and dose-related depression of delta-aminolevulinate dehydratase activity in liver, bone marrow, and erythrocytes (Fujita et al. 1984 Koizumi et al. 1984). Related effects included increased delta-aminolevulinic acid (ALA) synthetase activity, reduced heme saturation of tryptophan pyrrolase and reduced cytochrome P-450 levels in the liver and increased urinary excretion of... 

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