Delta-aminolevulinic acid dehydratase ALAD

Dieter, M.P. 1979. Blood delta-aminolevulinic acid dehydratase (ALAD) to monitor lead contamination in canvasback ducks (Aythya valisineria). Pages 177-191 in National Academy of Sciences. Animals as Monitors of Environmental Pollutants. Washington, D.C. 

Burns CB, Godwin IR. 1991. A comparison of the effects of inorganic and alkyllead compounds on human erythrocytic delta-aminolevulinic-acid dehydratase (ALAD) activity in vitro. J Appl Toxicol 11 103-111. 

Rainbo v trout exposed to supernatant waste developed general stress symptoms at 13-15 °C, and plasma hypocalcemia and sex-dependent inhibition of erythrocytic delta-aminolevulinic acid dehydratase (ALAD) enzyme activity at 7-8°C (Lehtinen etal. 1984). 

Bergdahl, LA., A. Grubb, A. Schutz, R.J. Desnick, J.G. Wetmur, S. Sassa, and S. Sker-fving. 1997. Lead binding to delta-aminolevulinic acid dehydratase (ALAD) in human erythrocytes. Pharmacol. Toxicol. 81(4) 153-158. 

Rajan, P., K.T. Kelsey, J.C. Schwartz, D.C. Belhnger, J. Weuve, D. Sparrow, A. Spiro, ni, T. J. Smith, H. Nie, H. Hu, and R.O. Wright. 2007. Lead burden and psychiatric symptoms and the modifying influence of the delta-aminolevulinic acid dehydratase (ALAD) polymorphism The VA Normative Aging Study. Am. J. Epidemiol. 166(12) 1400-1408. 

Pb levels of 100 [Jig/dL or more. Evidence from other sources (see Grand) ean ) has suggested that measurement of zinc protoporph3 in (ZPP) and, at lower exposure levels, delta-aminolevulinic acid dehydratase (ALAD) may have higher predictive validity than blood Pb analysis. Additional biological indices of Pb exposure have also been discussed by Posner et al. ... 

Delta aminolevulinic-acid dehydratase (ALAD) is perhaps the most widely studied heme-related enzyme that is altered by metal contamination. ALAD conjugates two aminolevulinic acid molecules critical to heme biosynthesis. The zinc-dependant enzyme is easily inhibited by lead substitution and has been extensively characterized as a sensitive indicator of lead exposure. Blood is the ideal matrix for assessing ALAD activity in wildlife, and sampling is easy and non-lethal. Decreased ALAD activity has been correlated to lead accumulation in a wide variety of birds such as waterfowl, game birds, raptors, and passerines (28, 42, 53, 54, 90-92). 

ALAD = delta-aminolevulinic acid dehydratase DMSA= dimercaptosuccinic acid NMDA= N-methyl- D-aspartate PCBs = polychlorinated biphenyls XRF = X-ray fluorescence... 

EXDVXXGXPPAA Delta-aminolevulinic acid dehydratase, chloroplast precursor (porphobilinogen synthase) (ALADH) (ALAD)/ 60-94 Selaginella martensii 100% 0.05... 

Purwoningsih, E. (2008). Effect of molecular weight chitosan against levels plumbum (Pb) blood and enzyme activily-Alad 5 (delta aminolevulinic acid dehydratase) Albino mice (Mus Musculus L) healthcare. Master Thesis, University of North Sumatra, Medan. 

Abbreviations ALAD, delta-aminolevulinic acid dehydratase ANOVA, analysis of variance BLL, blood lead level Hgb, hemoglobm HCT, hematocrit ZPP, zinc protoporphyrin. 

Abbreviations ALAD, delta-aminolevulinic acid dehydratase CBLI, cumulative blood lead index HR, hazard ratio NHANES, National Health and Nutrition Examination Survey (II = second survey, HI = third survey) OR, odds ratio OSHA, Occupational Safety and Health Administration PLEA, petrol-lead emission area RR, relative risk SE, standard error, SIR, standardized incidence ratio SMR, standardized mortality ratio. 

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