Dehydrocholic acid

The hydrolysis of dehydrocholic acid trishemithioketal (29) can be performed selectively to yield the 7,12-bishemithioketal (30), the 12-monohemi-thioketal (31) or the free triketone (32). ... 

C24H4q05 81 -25-4) see Chenodeoxycholic acid Dehydrocholic acid choline chloride... 

By means of B. coli crotyl alcohol (2-butene-l-ol) can be slowly reduced phytochemically to n-butanol. The same bacterium does not attack cinnamyl alcohol, but does slowly convert dehydrocholic acid to 7-hydroxy-3,12-diketocholic acid. ... 

In the bile cholesterol is kept soluble by fats, phospholipids like lecithin and by bile acids. The important bile acids in human bile are cholic acid, chen-odeoxycholic acid or chenodiol and ursodeoxycholic acid or ursodiol. Bile acids increase bile production. Dehydrocholic acid, a semisynthetic cholate is especially active in this respect. It stimulates the production of bile of low specific gravity and is therefore called a hydrocholeretic drug. Chenodiol and ursodiol but not cholic acid decrease the cholesterol content of bile by reducing cholesterol production and cholesterol secretion. Ursodiol also decreases cholesterol reabsorption. By these actions chenodiol and ursodiol are able to decrease the formation of cholesterolic gallstones and they can promote their dissolution. 

The alkaloids corydine, bulbocapnine, and isocorydine have an adrenolytic effect (427, 428). All of them, including glaucine, act cholinergically (429, 430) this effect is, however, smaller than that of dehydrocholic acid. For the synthesis and pharmacology of aporphine, the pharmacology of (— )-nornuciferine and of pukateine, see Kupchan, et al. (379), Weisbach et al. (431), and Smith et al. (432, 433), Burkman and Cannon (434), and Fogg (435). 

The addition of activated charcoal or dehydrocholic acid to the feed, protected animals (C57BL/6J mice, CD-COBS rats, and guinea pigs) from increased mortality caused by a single lethal dose of... 

Common Name Acide dehydrocholique Acidum dehydrocholicum Acidum trioxocholanicum Dehydrocholic acid Dehydrocholsaeure Ketocholanic acid... 

To a chromatographic column, packed with 6.67 g of charcoal ("Nuchar C") with layers of sea sand at either end, 75 ml of acetone was added to wet the carbon. The column was heated to 40°C, and 25 ml of acetone was drained off. A solution of 20 g of dry crude dehydrocholic acid in 500 ml of acetone was poured into a reservoir atop the column and maintained in this reservoir at 40°C. This solution was then allowed to drop through the column at a constant rate over a 3-hour period. The column was then washed with 250 ml of acetone flowing through the column at a constant rate over a 1-hour-period at 40°C. The column effluent and wash acetone were combined and concentrated to a residual volume of about 100 ml which resulted in the formation of a thick slurry. The slurry was cooled with stirring at 0° to 5°C and aged for 30 min at this temperature. The slurry was filtered and the filter cake washed with cold acetone. The filter cake of U.S.P. dehydrocholic acid was sucked partially dry on the filter and then dried at 110°C for 3 hours. 

A second crop of crystals was obtained from the combined filtrate and wash liquid from the first crop filtration. This mixture, which initially had a volume of about 100 ml, was concentrated to 20 ml. 10 ml of water was added to the solution and 10 ml of acetone mixed with a small amount of water distilled off. The residual thick slurry of dehydrocholic acid was cooled to 0-5°C, aged at... 

Combinations of Electrolytes and Nonelectrolytes. Combinations of nonelectrolytes and electrolytes were often found to be superior to either alone at improving percutaneous absorption of DIL and DSCG. In particular, the bioavailability of DIL was increased remarkably by BL-9EX/TLP-4, Vifpant N/TLP-4, urea/TLP-4, urea/sacrosinate LN and urea/dehydrocholic acid. It is... 

Zempl i, of aldononitriles, IV, 138 AVDehydroandrosterone, IV, 93 Dehydrocholic acid, IV, 106 Dehydrodesoxycholic acid, IV, 92 Dehydrohalogenation, of halo carbohydrates, III, 102 Density of cellulosic fibers, V, 121 Depolymerase, action on pectic acids, V, 82, 92... 

Yang s chiral ketones 75 have also been used as catalysts in the kinetic resolution of acyclic secondary allyl silyl ethers <2001JOC4619>. Dioxiranes generated in situ from dehydrocholic acid derivatives 122 and Oxone have been used in the asymmetric epoxidations of cinnamic acid derivatives with product ee s up to 95% <2001TA1113, 2002JOC5802> and unfunctionalized olefins (up to 98% ee) <2006T4482>. 

Dehydrocholic acid produces thin watery bile and so it is used to flush small calculi out of the bile ducts, particularly after surgery. 

Choleretic agents stimulate the secretion of bile by the liver, thereby increasing the flow of bile. Examples include chenodeoxycholic acid, ursodeoxycholic acid and a semisynthetic cholate, dehydrocholic acid. Chenodeoxycholic acid appears to work by inhibiting HMG-CoA reductase. Dehydrocholic acid produces thin watery bile, so is used to flush small calculi out of the bile ducts, particularly after surgery. These agents are discussed in more detail in other articles see ANTIHYPERLIPIDAEMIC AGENTS CHOLERETIC AGENTS HMG-COA REDUCTASE INHIBITORS. 

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