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Deep-brain stimulation

DBS deep brain stimulation GEF guanine nucleotide exchange factor... [Pg.964]

Husted DS, Shapira NA. A review of the treatment for refractory obsessive-compulsive disorder from medicine to deep brain stimulation. CNS Spectr 2004 9 833-847. [Pg.175]

Lang AE, Widner H. Deep brain stimulation for Parkinson s disease patient selection and evaluation. Mov Disord 2002 17 Suppl. 3 S94-101. [Pg.705]

In patients with advanced disease that is poorly responsive to pharmacotherapy, worthwhile benefit may follow thalamotomy (for conspicuous tremor) or posteroventral pallidotomy. Ablative surgical procedures, however, have generally been replaced by functional, reversible lesions induced by high-frequency deep brain stimulation, which has a lower morbidity. [Pg.612]

In patients with severe parkinsonism and long-term complications of levodopa therapy such as the on-off phenomenon, a trial of treatment with a COMT inhibitor or rasagiline may be helpful. Regulation of dietary protein intake may also improve response fluctuations. Deep brain stimulation is often helpful in patients who fail to respond adequately to these measures. Treating patients who are young or have mild parkinsonism with rasagiline may delay disease progression and merits consideration. [Pg.613]

The pharmacologic basis of these disorders is unknown, and there is no satisfactory medical treatment for them. A subset of patients respond well to levodopa medication (dopa-responsive dystonia), which is therefore worthy of trial. Occasional patients with dystonia may respond to diazepam, amantadine, antimuscarinic drugs (in high dosage), carbamazepine, baclofen, haloperidol, or phenothiazines. A trial of these pharmacologic approaches is worthwhile, though often not successful. Patients with focal dystonias such as blepharospasm or torticollis often benefit from injection of botulinum toxin into the overactive muscles. The role of deep brain stimulation for the treatment of these conditions is being explored. [Pg.616]

Benabid AL What the future holds for deep brain stimulation. Expert Rev Med Devices 2007 4 895. [PMID 18035954]... [Pg.622]

Maciunas RJ et al Prospective randomized double-blind trial of bilateral thalamic deep brain stimulation in adults with Tourette syndrome. J Neurosurg 2007 107 1004. [PMID 17977274]... [Pg.623]

Mink JW et al Patient selection and assessment recommendations for deep brain stimulation in Tourette syndrome. Mov Disord 2006 21 1831. [PMID 16991144]... [Pg.623]

Perlmutter JS, Mink JW Deep brain stimulation. Annu Rev Neurosci 2006 29 229. [PMID 16776585]... [Pg.623]

Servello D et al Deep brain stimulation in 18 patients with severe Gilles de la Tourette syndrome refractory to treatment the surgery and stimulation. J Neurol Neurosurg Psychiatry 2008 79 136. [PMID 17846115]... [Pg.624]

Ashkan K, Wallace B, Bell BA, Benabid AL. Deep brain stimulation of the subthalamic nucleus in Parkinson s disease 1993-2003 where are we 10 years on Br J Neurosurg. 2004 18 19-34. [Pg.132]

Lozano AM, Mahant N. Deep brain stimulation surgery for Parkinson s disease mechanisms and consequences. Parkinsonism Relat Disord. 2004 10(suppl 1) S49-S57. [Pg.133]

P. A. Tass Desynchronizing double-pulse phase resetting and application to deep brain stimulation. Biol. Cybern. 2001, 85 343-344. [Pg.59]

Toward a Computational Model of Deep Brain Stimulation in Parkinson s Disease... [Pg.349]

Gross C., Guehl D. Effect of deep brain stimulation on amplitude and frequency characteristics of rest tremor in Parkinson s disease. Thalamus Relat Syst, 2001,... [Pg.369]

Beuter A., Titcombe M. Modulation of tremor amplitude during deep brain stimulation at different frequencies. Brain and Cognition, 2003, 53, 210-212. [Pg.369]

Butson C.R., Cooper S.E., McIntyre C.C. Deep brain stimulation of the subthalamic nucleus Patient specific analysis of the volume of tissue activated. 10th Annual Conference of the International FES Society, July 2005, Montreal, Canada. [Pg.369]

Gang L., Chao Y., Ling L., Lu S.C. Uncovering the mechanisms of Deep Brain Stimulation. Journal of Physics Conference Series, 2005, 13, 336-344. [Pg.369]

Hauptmann C., Popovych O., Tass P. A. Effectively desynchronizing deep brain stimulation based on a coordinated delayed feedback stimulation via several sites a computational study. Biol Cybem,... [Pg.369]

Kopell B.H., Rezai A.R., Chang J.W., Vitek J.L. Anatomy and physiology of the basal ganglia implications for deep brain stimulation for Parkinson s disease. Mov Disord, 2006, 21,14, 238-246. [Pg.370]

Kuncel A.M., Grill W.M. Selection of stimulus parameters for deep brain stimulation. Clin Neurophysiol, 2004, 225(11), 2431-2441. [Pg.370]

Grill W.M., McIntyre C.C. Extracellular excitation of central neurons implications for the mechanisms of deep brain stimulation. Thalamus Relat Syst, 2001, 2, 269-277. [Pg.370]

McIntyre C.C., Savasta M., Walter B.L., Vitek J.L. How does deep brain stimulation work Present understanding and future questions. J Clin Neurophysiol, 2004, 40-50. [Pg.370]

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